ReviewMechanisms of ageing and development2007
Extended longevity mechanisms in short-lived progeroid mice: identification of a preservative stress response associated with successful aging.
Review in Mechanisms of ageing and development, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- Article
- DNA damage, inflammation and aging: Insights from mice.Frontiers in aging · 2022Review
- The splicing factor XAB2 interacts with ERCC1-XPF and XPG for R-loop processing.Nature communications · 2021Article
- Tissue-infiltrating macrophages mediate an exosome-based metabolic reprogramming upon DNA damage.Nature communications · 2020Article
- Genomic Approach to Understand the Association of DNA Repair with Longevity and Healthy Aging Using Genomic Databases of Oldest-Old Population.Oxidative medicine and cellular longevity · 2018Review
- Increased oxidative phosphorylation in response to acute and chronic DNA damage.NPJ aging and mechanisms of disease · 2016Article
- Aag-initiated base excision repair promotes ischemia reperfusion injury in liver, brain, and kidney.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Lifespan extension by dietary intervention in a mouse model of Cockayne syndrome uncouples early postnatal development from segmental progeria.Aging cell · 2013Article
- Analysis of osteoarthritis in a mouse model of the progeroid human DNA repair syndrome trichothiodystrophy.Age (Dordrecht, Netherlands) · 2011Article
- Differentiation driven changes in the dynamic organization of Basal transcription initiation.PLoS biology · 2009Article
- Congenital DNA repair deficiency results in protection against renal ischemia reperfusion injury in mice.Aging cell · 2009Article
- An Xpb mouse model for combined xeroderma pigmentosum and cockayne syndrome reveals progeroid features upon further attenuation of DNA repair.Molecular and cellular biology · 2009Article
- Homeostatic imbalance between apoptosis and cell renewal in the liver of premature aging Xpd mice.PloS one · 2008Article
- How does suppression of IGF-1 signaling by DNA damage affect aging and longevity?Mechanisms of ageing and development · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
Abstract
Semantic distinctions between "normal" aging, "pathological" aging (or age-related disease) and "premature" aging (otherwise known as segmental progeria) potentially confound important insights into the nature of each of the complex processes. Here we review a recent, unexpected discovery: the presence of longevity-associated characteristics typical of long-lived endocrine-mutant and dietary-restricted animals in short-lived progeroid mice. These data suggest that a subset of symptoms observed in premature aging, and possibly normal aging as well, may be indirect manifestations of a beneficial adaptive stress response to endogenous oxidative damage, rather than a detrimental result of the damage itself.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.