ArticleCell regulation1990
Nuclear receptors for retinoic acid and thyroid hormone regulate transcription of keratin genes.
Article in Cell regulation, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 97 citations in OpenAlex.
- Functional characterization of theHeliyon · 2024Article
- Article
- Common tumor-suppressive signaling of thyroid hormone receptor beta in breast and thyroid cancer cells.Molecular carcinogenesis · 2021Article
- The Retinol Circulating Complex Releases Hormonal Ligands During Acute Stress Disorders.Frontiers in endocrinology · 2018Review
- Retinoic acid signaling regulates Krt5 and Krt14 independently of stem cell markers in submandibular salivary gland epithelium.Developmental dynamics : an official publication of the American Association of Anatomists · 2017Article
- Nuclear hormone receptor functions in keratinocyte and melanocyte homeostasis, epidermal carcinogenesis and melanomagenesis.FEBS letters · 2013Review
- Triiodothyronine represses MUC5AC expression by antagonizing Sp1 binding to its promoter in human bronchial epithelial HBE16 cells.Journal of biomedicine & biotechnology · 2012Article
- Thyroid hormone action on skin.Dermato-endocrinology · 2011Article
- Article
- Expression, localisation and functional activation of NFAT-2 in normal human skin, psoriasis, and cultured keratocytes.International journal of clinical and experimental medicine · 2009Article
- Nexus between epidermolysis bullosa and transcriptional regulation by thyroid hormone in epidermal keratinocytes.Clinical and translational science · 2008Article
- Thyroid hormones and gamma interferon specifically increase K15 keratin gene transcription.Molecular and cellular biology · 2004Article
- Regulation of mucin gene expression in human tracheobronchial epithelial cells by thyroid hormone.The Biochemical journal · 2001Article
- Novel mechanism of steroid action in skin through glucocorticoid receptor monomers.Molecular and cellular biology · 2000Article
- Constitutive activation of gene expression by thyroid hormone receptor results from reversal of p53-mediated repression.Molecular and cellular biology · 1997Article
- Inhibition of TGF-alpha gene expression by vitamin A in airway epithelium.The Journal of clinical investigation · 1996Article
- Oct-6: a regulator of keratinocyte gene expression in stratified squamous epithelia.Molecular and cellular biology · 1994Article
- The conserved ninth C-terminal heptad in thyroid hormone and retinoic acid receptors mediates diverse responses by affecting heterodimer but not homodimer formation.Molecular and cellular biology · 1993Article
- Probing keratinocyte and differentiation specificity of the human K5 promoter in vitro and in transgenic mice.Molecular and cellular biology · 1993Article
- On the role of AP2 in epithelial-specific gene expression.Gene expression · 1993Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
In the epidermis, retinoids regulate the expression of keratins, the intermediate filament proteins of epithelial cells. We have cloned the 5' regulatory regions of four human epidermal keratin genes, K#5, K#6, K#10, and K#14, and engineered constructs in which these regions drive the expression of the CAT reporter gene. By co-transfecting the constructs into epithelial cells along with the vectors expressing nuclear receptors for retinoic acid (RA) and thyroid hormone, we have demonstrated that the receptors can suppress the promoters of keratin genes. The suppression is ligand dependent; it is evident both in established cell lines and in primary cultures of epithelial cells. The three RA receptors have similar effects on keratin gene transcription. Our data indicate that the nuclear receptors for RA and thyroid hormone regulate keratin synthesis by binding to negative recognition elements in the upstream DNA sequences of the keratin genes. RA thus has a twofold effect on epidermal keratin expression: qualitatively, it regulates the regulators that effect the switch from basal cell-specific keratins to differentiation-specific ones; and quantitatively, it determines the level of keratin synthesis within the cell by direct interaction of its receptors with the keratin gene promoters.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.