ArticleCell calcium2007
Ca2+ signal summation and NFATc1 nuclear translocation in sympathetic ganglion neurons during repetitive action potentials.
Article in Cell calcium, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 32 citations in OpenAlex.
- The Unified Theory of Neurodegeneration Pathogenesis Based on Axon Deamidation.International journal of molecular sciences · 2025Review
- New Insights in CaVβ Subunits: Role in the Regulation of Gene Expression and Cellular Homeostasis.Frontiers in cell and developmental biology · 2022Review
- More than a pore: How voltage-gated calcium channels act on different levels of neuronal communication regulation.Channels (Austin, Tex.) · 2021Review
- Voltage sensor movements of CaProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Near-UV Light Induced ROS Production Initiates Spatial CaInternational journal of molecular sciences · 2021Article
- Circuit-Specific Early Impairment of Proprioceptive Sensory Neurons in the SOD1The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Review
- The Physiology, Pathology, and Pharmacology of Voltage-Gated Calcium Channels and Their Future Therapeutic Potential.Pharmacological reviews · 2015Review
- Nuclear factor of activated T cells is activated in the endothelium of retinal microvessels in diabetic mice.Journal of diabetes research · 2015Article
- Article
- Activity-dependent transcriptional regulation of M-Type (Kv7) K(+) channels by AKAP79/150-mediated NFAT actions.Neuron · 2012Article
- Article
- AKAP79/150 signal complexes in G-protein modulation of neuronal ion channels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- A fluorescence-based assay to monitor transcriptional activity of NFAT in living cells.The Journal of physiology · 2010Article
- Augmentation of Cav1 channel current and action potential duration after uptake of S100A1 in sympathetic ganglion neurons.American journal of physiology. Cell physiology · 2009Article
- Mitochondrial Ca2+ cycling facilitates activation of the transcription factor NFAT in sensory neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Regulation of nuclear factor of activated T cells (NFAT) in vascular endothelial cells.Journal of molecular and cellular cardiology · 2009Article
- Ion channels in mammalian vestibular afferents may set regularity of firing.The Journal of experimental biology · 2008Review
- NFAT signaling in neural development and axon growth.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2008Review
- Deafferentation-induced activation of NFAT (nuclear factor of activated T-cells) in cochlear nucleus neurons during a developmental critical period: a role for NFATc4-dependent apoptosis in the CNS.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
NFATc-mediated gene expression constitutes a critical step during neuronal development and synaptic plasticity. Although considerable information is available regarding the activation and functionality of specific NFATc isoforms, in neurons little is known about how sensitive NFAT nuclear translocation is to specific patterns of electrical activity. Here we used high-speed fluo-4 confocal imaging to monitor action potential (AP)-induced cytosolic Ca2+ transients in rat sympathetic neurons. We have recorded phasic and repetitive AP patterns, and corresponding Ca2+ transients initiated by either long (100-800 ms) current-clamp pulses, or single brief (2 ms) electrical field stimulation. We address the functional consequences of these AP and Ca2+ transient patterns, by using an adenoviral construct to express NFATc1-CFP and evaluate NFATc1-CFP nuclear translocation in response to specific patterns of electrical activity. Ten Hertz trains stimulation induced nuclear translocation of NFATc1, whereas 1 Hz trains did not. However, 1 Hz train stimulation did result in NFATc1 translocation in the presence of 2 mM Ba2+, which inhibits M-currents and promotes repetitive firing and the accompanying small (approximately 0.6 DeltaF/F0) repetitive and summating Ca2+ transients. Our results demonstrate that M-current inhibition-mediated spike frequency facilitation enhances cytosolic Ca2+ signals and NFATc1 nuclear translocation during trains of low frequency electrical stimulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.