ArticleMalaria journal2006
Scanning electron microscopy of the neuropathology of murine cerebral malaria.
Article in Malaria journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
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- Transcellular blood-brain barrier disruption in malaria-induced reversible brain edema.Life science alliance · 2022Article
- The Artemiside-Artemisox-Artemisone-M1 Tetrad: Efficacies against Blood StagePharmaceutics · 2021Article
- Neglected interstitial space in malaria recurrence and treatment.Nano research · 2020Article
- Tissue-specific immunopathology during malaria infection.Nature reviews. Immunology · 2018Review
- Perivascular Arrest of CD8+ T Cells Is a Signature of Experimental Cerebral Malaria.PLoS pathogens · 2015Article
- Electron microscopic features of brain edema in rodent cerebral malaria in relation to glial fibrillary acidic protein expression.International journal of clinical and experimental pathology · 2014Article
- Identification of the Plasmodium berghei resistance locus 9 linked to survival on chromosome 9.Malaria journal · 2013Article
- Improvement of the efficacy of dihydroartemisinin with atorvastatin in an experimental cerebral malaria murine model.Malaria journal · 2013Article
- Impact of methylene blue and atorvastatin combination therapy on the apparition of cerebral malaria in a murine model.Malaria journal · 2013Article
- Atorvastatin prevents Plasmodium falciparum cytoadherence and endothelial damage.Malaria journal · 2011Article
- Article
- Elevated cell-specific microparticles are a biological marker for cerebral dysfunctions in human severe malaria.PloS one · 2010Article
- Inflammatory changes in the central nervous system are associated with behavioral impairment in Plasmodium berghei (strain ANKA)-infected mice.Experimental parasitology · 2010Article
- Algorithms to predict cerebral malaria in murine models using the SHIRPA protocol.Malaria journal · 2010Article
- Sepsis-associated encephalopathy: a magnetic resonance imaging and spectroscopy study.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2010Article
- Sporulation in mycobacteria.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Glatiramer acetate reduces the risk for experimental cerebral malaria: a pilot study.Malaria journal · 2009Article
- Complement factors C1q, C3 and C5 in brain and serum of mice with cerebral malaria.Malaria journal · 2008Article
- Germinal center architecture disturbance during Plasmodium berghei ANKA infection in CBA mice.Malaria journal · 2007Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe mechanisms leading to death and functional impairments due to cerebral malaria (CM) are yet not fully understood. Most of the knowledge about the pathomechanisms of CM originates from studies in animal models. Though extensive histopathological studies of the murine brain during CM are existing, alterations have not been visualized by scanning electron microscopy (SEM) so far. The present study investigates the neuropathological features of murine CM by applying SEM.
methodsC57BL/6J mice were infected with Plasmodium berghei ANKA blood stages. When typical symptoms of CM developed perfused brains were processed for SEM or light microscopy, respectively.
resultsUltrastructural hallmarks were disruption of vessel walls, parenchymal haemorrhage, leukocyte sequestration to the endothelium, and diapedesis of macrophages and lymphocytes into the Virchow-Robin space. Villous appearance of observed lymphocytes were indicative of activated state. Cerebral oedema was evidenced by enlargement of perivascular spaces.
conclusionThe results of the present study corroborate the current understanding of CM pathophysiology, further support the prominent role of the local immune system in the neuropathology of CM and might expose new perspectives for further interventional studies.
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