ArticleProceedings of the National Academy of Sciences of the United States of America1991
Coordinate regulation of HOX genes in human hematopoietic cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
43 citing papers in PubMed, 169 citations in OpenAlex.
- The Effect of Endometrial Polyp and Myoma Uteri on Fertility-Related Genes in the Endometrium.Reproductive sciences (Thousand Oaks, Calif.) · 2025Article
- Paralogous HOX13 Genes in Human Cancers.Cancers · 2019Review
- The posterior HOXD locus: Its contribution to phenotype and malignancy of Ewing sarcoma.Oncotarget · 2016Article
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- HOXA10 controls proliferation, migration and invasion in oral squamous cell carcinoma.International journal of clinical and experimental pathology · 2015Article
- MicroRNA-196a promotes non-small cell lung cancer cell proliferation and invasion through targeting HOXA5.BMC cancer · 2012Article
- Increased HoxB4 Inhibits Apoptotic Cell Death in Pro-B Cells.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2012Article
- miRNAs and Melanoma: How Are They Connected?Dermatology research and practice · 2012Article
- Zebrafish mll gene is essential for hematopoiesis.The Journal of biological chemistry · 2011Article
- Conditional Tet-regulated over-expression of Hoxa2 in CG4 cells increases their proliferation and delays their differentiation into oligodendrocyte-like cells expressing myelin basic protein.Cellular and molecular neurobiology · 2011Article
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- Expression pattern of the class I homeobox genes in ovarian carcinoma.Journal of gynecologic oncology · 2010Article
- Regulation of mir-196b by MLL and its overexpression by MLL fusions contributes to immortalization.Blood · 2009Article
- Global and Hox-specific roles for the MLL1 methyltransferase.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
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- The proline-rich homeodomain (PRH/HEX) protein is down-regulated in liver during infection with lymphocytic choriomeningitis virus.Journal of virology · 2005Article
- Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease.The EMBO journal · 2005Article
- Hyperexpression of locus C genes in the HOX network is strongly associated in vivo with human bladder transitional cell carcinomas.Oncogene · 2003Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hematopoiesis is a continuous process in which precursor cells proliferate and differentiate throughout life. However, the molecular mechanisms that govern this process are not clearly defined. Homeobox-containing genes, encoding DNA-binding homeodomains, are a network of genes highly conserved throughout evolution. They are organized in clusters expressed in the developing embryo with a positional hierarchy. We have analyzed expression of the four human HOX loci in erythroleukemic, promyelocytic, and monocytic cell lines to investigate whether the physical organization of human HOX genes reflects a regulatory hierarchy involved in the differentiation process of hematopoietic cells. Our results demonstrate that cells representing various stages of hematopoietic differentiation display differential patterns of HOX gene expression and that HOX genes are coordinately switched on or off in blocks that may include entire loci. The entire HOX4 locus is silent in all lines analyzed and almost all the HOX2 genes are active in erythroleukemic cells and turned off in myeloid-restricted cells. Our observations provide information about the regulation of HOX genes and suggest that the coordinate regulation of these genes may play an important role in lineage determination during early steps of hematopoiesis.
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