ArticleProceedings of the National Academy of Sciences of the United States of America1991
The Barr body is a looped X chromosome formed by telomere association.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- The role of spatiotemporal organization and dynamics of clock complexes in circadian regulation.Current opinion in cell biology · 2022Review
- Fragile sites, chromosomal lesions, tandem repeats, and disease.Frontiers in genetics · 2022Review
- Clock proteins regulate spatiotemporal organization of clock genes to control circadian rhythms.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Structural aspects of the inactive X chromosome.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Role of Inner Nuclear Membrane Protein Complex Lem2-Nur1 in Heterochromatic Gene Silencing.The Journal of biological chemistry · 2016Article
- Bipartite structure of the inactive mouse X chromosome.Genome biology · 2015Article
- Massive interstitial copy-neutral loss-of-heterozygosity as evidence for cancer being a disease of the DNA-damage response.BMC medical genomics · 2015Article
- Gene density and chromosome territory shape.Chromosoma · 2014Article
- Chromosome territories, X;Y translocation and Premature Ovarian Failure: is there a relationship?Molecular cytogenetics · 2009Article
- Nature of telomere dimers and chromosome looping in human spermatozoa.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2004Article
- Identification of an autoimmune serum containing antibodies against the Barr body.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Gene silencing via protein-mediated subcellular localization of DNA.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Persistence of an alternate chromatin structure at silenced loci in vitro.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Three-dimensional reconstruction of painted human interphase chromosomes: active and inactive X chromosome territories have similar volumes but differ in shape and surface structure.The Journal of cell biology · 1996Article
- The clustering of telomeres and colocalization with Rap1, Sir3, and Sir4 proteins in wild-type Saccharomyces cerevisiae.The Journal of cell biology · 1996Article
- An analysis of Xq deletions.Human genetics · 1996Article
- XIST RNA paints the inactive X chromosome at interphase: evidence for a novel RNA involved in nuclear/chromosome structure.The Journal of cell biology · 1996Article
- Impact of rearrangements on function and position of chromosomes in the interphase nucleus and on human genetic disorders.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 1995Review
- Well-defined genome architecture in the human sperm nucleus.Chromosoma · 1995Article
- Splicing components are excluded from the transcriptionally inactive XY body in male meiotic nuclei.Molecular biology of the cell · 1994Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
We examined Barr bodies formed by isodicentric human X chromosomes in cultured human cells and in mouse-human hybrids using confocal microscopy and DNA probes for centromere and subtelomere regions. At interphase, the two ends of these chromosomes are only a micron apart, indicating that these inactive X chromosomes are in a nonlinear configuration. Additional studies of normal X chromosomes reveal the same telomere association for the inactive X but not for the active X chromosome. This nonlinear configuration is maintained during mitosis and in a murine environment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.