ArticleEuropean journal of clinical pharmacology2007
The awareness among paediatricians of off-label prescribing in children: a survey of Italian hospitals.
Article in European journal of clinical pharmacology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Off-label medication use in pediatrics and associated factors at public hospitals in east Gojjam zone, Ethiopia.SAGE open medicine · 2022Article
- Exploratory Findings of Prescribing Unlicensed and Off-Label Medicines Among Children and Neonates.Integrated pharmacy research & practice · 2020Article
- Attitudes, knowledge and views on off-label prescribing in children among healthcare professionals in Malaysia.International journal of clinical pharmacy · 2019Article
- The Unlicensed and Off-label Prescription of Medications in General Paediatric Ward: An Observational Study.Current pediatric reviews · 2019Observational
- Off-label drugs use in pediatric palliative care.Italian journal of pediatrics · 2018Article
- Maltese prescribers use of off-label and unlicensed medicines in children: perceptions and attitudes.International journal of clinical pharmacy · 2016Article
- Article
- Perceptions and attitudes of Jordanian paediatricians towards off-label paediatric prescribing.International journal of clinical pharmacy · 2011Article
- Healthcare professional experiences and attitudes on unlicensed/off-label paediatric prescribing and paediatric clinical trials.European journal of clinical pharmacology · 2011Article
- Off-label antibiotic use in children in three European countries.European journal of clinical pharmacology · 2010Article
- Efficacy and safety of angiotensin II receptor type 1 antagonists in children and adolescents.Pediatric nephrology (Berlin, Germany) · 2010Review
- Off-label use of medicines in children: can available evidence avoid useless paediatric trials? The case of proton pump inhibitors for the treatment of gastroesophageal reflux disease.European journal of clinical pharmacology · 2009Article
- Review
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Authors and funding
7 authors.
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Abstract
objectiveTo investigate paediatricians' perception and awareness of off-label (OL) and unlicensed drug usage in clinical practice.
methodsWe conducted a questionnaire-based, observational study involving 28 departments/specialty units of four tertiary paediatrics Italian hospitals. The questionnaire was sent to a designated paediatrician in each department/specialty unit with the request that they summarise their awareness of OL prescriptions after a group discussion with all paediatricians working in the same department/unit.
resultsA total of 95 drugs were identified. The most common perceived reasons detected for OL use were age and formulation. Corticosteroids, ACE-inhibitors, beta-blockers and calcium-antagonists were most frequently indicated as OL for formulation, while ACE-inhibitors, new generation anti-epilepsy drugs, immunosuppressants, ketorolac and propofol as OL for age. Adrenaline, midazolam and ACE-inhibitors were indicated as unlicensed for route of administration. We found a high concordance between the OL drugs identified by physicians and those reported in the "Italian Summary Product Characteristics".
conclusionsItalian paediatricians perceived different drugs as unlicensed/OL from those identified by existing prescriptions studies. These perceived drugs may represent a priority in tackling the problem of OL usage in the hospital practice. The review of the Italian Summary Product Characteristics of some of the drugs identified, together with the monitoring of permanent clinical practice and with new clinical research, may be a step forward to reduce OL use in children.
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