ArticleThe EMBO journal2006
Prepubertal testis development relies on retinoic acid but not rexinoid receptors in Sertoli cells.
Article in The EMBO journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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Who cites it
60 citing papers in PubMed, 116 citations in OpenAlex.
- Retinoid-X receptor action and disruption in development.Developmental biology · 2026Review
- Transcriptome analysis of the hypothalamus and testes in Brandt's Vole: new insights into mechanisms of photoperiodic plasticity in postnatal testicular development.Functional & integrative genomics · 2025Article
- Sertoli cells as a hub in testicular development and male reproductive.Frontiers in cell and developmental biology · 2025Review
- Microenvironment of spermatogonial stem cells: a key factor in the regulation of spermatogenesis.Stem cell research & therapy · 2024Review
- Loss of function of male-specific lethal 3 (Msl3) does not affect spermatogenesis in rodents.Developmental dynamics : an official publication of the American Association of Anatomists · 2024Article
- Targeting nuclear receptor corepressors for reversible male contraception.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Multiple ageing effects on testicular/epididymal germ cells lead to decreased male fertility in mice.Communications biology · 2024Article
- Differential responsiveness of spermatogonia to retinoic acid dictates precocious differentiation but not meiotic entry during steady-state spermatogenesis†.Biology of reproduction · 2023Article
- Follicle-stimulating hormone signaling in Sertoli cells: a licence to the early stages of spermatogenesis.Reproductive biology and endocrinology : RB&E · 2022Review
- Retinoic Acid Receptor Alpha Is Essential in Postnatal Sertoli Cells but Not in Germ Cells.Cells · 2022Article
- Review
- Macrophage ubiquitin-specific protease 2 contributes to motility, hyperactivation, capacitation, and in vitro fertilization activity of mouse sperm.Cellular and molecular life sciences : CMLS · 2021Article
- FSH regulates RA signaling to commit spermatogonia into differentiation pathway and meiosis.Reproductive biology and endocrinology : RB&E · 2021Review
- Retinoic acid signaling pathways.Development (Cambridge, England) · 2019Review
- Two functionally redundant sources of retinoic acid secure spermatogonia differentiation in the seminiferous epithelium.Development (Cambridge, England) · 2019Article
- The Ectopic Expression of Meiosis Regulatory Genes in Cutaneous T-Cell Lymphomas (CTCL).Frontiers in oncology · 2019Article
- Molecular Mechanisms and Signaling Pathways Involved in Sertoli Cell Proliferation.Frontiers in endocrinology · 2019Review
- Germ Cell-Specific Retinoic Acid Receptor α Functions in Germ Cell Organization, Meiotic Integrity, and Spermatogonia.Endocrinology · 2018Article
- Retinoic acid receptor signaling is necessary in steroidogenic cells for normal spermatogenesis and epididymal function.Development (Cambridge, England) · 2018Article
- Leydig cell genes change their expression and association with polysomes in a stage-specific manner in the adult mouse testis.Biology of reproduction · 2018Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sertoli cells (SC) are instrumental to stem spermatogonia differentiation, a process that critically depends on retinoic acid (RA). We show here that selective ablation of RA receptor alpha (RARalpha) gene in mouse SC, singly (Rara(Ser-/-) mutation) or in combination with RARbeta and RARgamma genes (Rara/b/g(Ser-/-) mutation), abolishes cyclical gene expression in these cells. It additionally induces testis degeneration and delays spermatogonial expression of Stra8, two hallmarks of RA deficiency. As identical defects are generated upon inactivation of RARalpha in the whole organism, our data demonstrate that all the functions exerted by RARalpha in male reproduction are Sertoli cell-autonomous. They further indicate that RARalpha is a master regulator of the cyclical activity of SC and controls paracrine pathways required for spermatogonia differentiation and germ cell survival. Most importantly, we show that the ablation of all RXR (alpha, beta and gamma isotypes) in SC does not recapitulate the phenotype generated upon ablation of all three RARs, thereby providing the first evidence that RARs exert functions in vivo independently of RXRs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.