ArticleProceedings of the National Academy of Sciences of the United States of America2006
Global modulation of chromatin dynamics mediated by dephosphorylation of linker histone H1 is necessary for erythroid differentiation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Analysis of the interplay between MeCP2 and histone H1 duringEpigenetics · 2023Article
- Overexpression of Rice Histone H1 Gene Reduces Tolerance to Cold and Heat Stress.Plants (Basel, Switzerland) · 2023Article
- Cellular dynamics of mammalian red blood cell production in the erythroblastic island niche.Biophysical reviews · 2019Review
- H1.0 Linker Histone as an Epigenetic Regulator of Cell Proliferation and Differentiation.Genes · 2018Review
- Role of H1 linker histones in mammalian development and stem cell differentiation.Biochimica et biophysica acta · 2016Review
- Photobleaching studies reveal that a single amino acid polymorphism is responsible for the differential binding affinities of linker histone subtypes H1.1 and H1.5.Biology open · 2016Article
- What is the role of histone H1 heterogeneity? A functional model emerges from a 50 year mystery.AIMS biophysics · 2015Article
- Silencing of IFN-stimulated gene transcription is regulated by histone H1 and its chaperone TAF-I.Nucleic acids research · 2014Article
- Developmentally regulated linker histone H1c promotes heterochromatin condensation and mediates structural integrity of rod photoreceptors in mouse retina.The Journal of biological chemistry · 2013Article
- Crucial role of dynamic linker histone binding and divalent ions for DNA accessibility and gene regulation revealed by mesoscale modeling of oligonucleosomes.Nucleic acids research · 2012Article
- N- and C-terminal domains determine differential nucleosomal binding geometry and affinity of linker histone isotypes H1(0) and H1c.The Journal of biological chemistry · 2012Article
- Histone H1 variants are differentially expressed and incorporated into chromatin during differentiation and reprogramming to pluripotency.The Journal of biological chemistry · 2011Article
- Geminin promotes neural fate acquisition of embryonic stem cells by maintaining chromatin in an accessible and hyperacetylated state.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Nucleosome interaction surface of linker histone H1c is distinct from that of H1(0).The Journal of biological chemistry · 2010Article
- Prothymosin alpha is a component of a linker histone chaperone.FEBS letters · 2010Article
- Dissecting the binding mechanism of the linker histone in live cells: an integrated FRAP analysis.The EMBO journal · 2010Article
- Chromatin condensation in terminally differentiating mouse erythroblasts does not involve special architectural proteins but depends on histone deacetylation.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2009Article
- Histone H1 of Trypanosoma cruzi is concentrated in the nucleolus region and disperses upon phosphorylation during progression to mitosis.Eukaryotic cell · 2008Article
- Physical plasticity of the nucleus in stem cell differentiation.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
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2 authors.
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Abstract
Differentiation of metazoan cells involves dramatic changes in gene expression patterns and proliferative capacity driven primarily by epigenetic mechanisms. Here we used in vivo photobleaching techniques and biochemical assays to investigate the contribution of alterations in chromatin dynamics to the differentiation of murine erythroleukemia (MEL) cells, a model system for erythroid development. As MEL cells differentiate the binding affinity of all linker histone variants increases, indicative of an overall decrease in chromatin flexibility. Changes in H1(0) binding properties depend on phosphorylation at one or more of three cyclin-dependent kinase sites. The presence of constructs mimicking constitutively phosphorylated H1 results in a significant inhibition in the acquisition of commitment to terminal cell division and the expression of erythroid-specific properties. These data indicate that the progressive loss of cdk activity associated with MEL cell differentiation leads to the accumulation of dephosphorylated linker histones and restricted chromatin flexibility and that these are necessary events in the progression of erythroid differentiation. We present additional data indicating that the presence of phosphorylated H1 has a dominant effect on the binding behavior of other linker histones and propose a model for the role of linker histone phosphorylation in which these modifications act within the context of assembled chromatin.
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