ArticleThe American journal of tropical medicine and hygiene2006
Aedes aegypti vectorial capacity is determined by the infecting genotype of dengue virus.
Article in The American journal of tropical medicine and hygiene, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
98 citing papers in PubMed, 1 synthesis or guideline pooled it, 206 citations in OpenAlex.
- Is there a risk of yellow fever virus transmission in South Asian countries with hyperendemic dengue?BioMed research international · 2013Pooled it
- Vector competence acrossJournal of virology · 2026Review
- Review
- Whole genome sequencing and phylogenetic analysis of dengue virus in Central Nepal from 2022 to 2023.BMC global and public health · 2025Article
- Estimation and Characterization of Dengue Serotypes in Patients Presenting with Dengue Fever at Makkah Hospitals.Tropical medicine and infectious disease · 2025Article
- Determining dengue infection risk in the Colombo district of Sri Lanka by inferencing the genetic parameters of Aedes mosquitoes.BMC infectious diseases · 2024Article
- In silico homology modeling of dengue virus non-structural 4B (NS4B) protein and its molecular docking studies using triterpenoids.BMC infectious diseases · 2024Article
- Comparative analysis of the susceptibility of Aedes aegypti and Japanese Aedes albopictus to all dengue virus serotypes.Tropical medicine and health · 2023Article
- Epidemiological and genomic analysis of dengue cases in Guangzhou, China, from 2010 to 2019.Scientific reports · 2023Article
- Interphase chromosomes of the Aedes aegypti mosquito are liquid crystalline and can sense mechanical cues.Nature communications · 2023Article
- The effect of temperature on dengue virus transmission byFrontiers in cellular and infection microbiology · 2023Review
- Not all mosquitoes are created equal: A synthesis of vector competence experiments reinforces virus associations of Australian mosquitoes.PLoS neglected tropical diseases · 2022Article
- Circulation of genotypes of dengue virus serotype 2 in Guangzhou over a period of 20 years.Virology journal · 2022Article
- Viral-Induced Inflammatory Coagulation Disorders: Preparing for Another Epidemic.Thrombosis and haemostasis · 2022Review
- Potential role of vector-mediated natural selection in dengue virus genotype/lineage replacements in two epidemiologically contrasted settings.Emerging microbes & infections · 2021Article
- Dengue and human health: A global scenario of its occurrence, diagnosis and therapeutics.Saudi journal of biological sciences · 2021Review
- Evolution and epidemiologic dynamics of dengue virus in Nicaragua during the emergence of chikungunya and Zika viruses.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2021Article
- The effects of DENV serotype competition and co-infection on viral kinetics in Wolbachia-infected and uninfected Aedes aegypti mosquitoes.Parasites & vectors · 2021Article
- Permethrin Resistance inInsects · 2021Article
- Chikungunya Virus Replication Rate Determines the Capacity of Crossing Tissue Barriers in Mosquitoes.Journal of virology · 2021Article
38 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Dengue viruses causing severe, hemorrhagic disease have displaced less virulent strains in the Americas during the past three decades. The American (AM) genotype of dengue serotype 2 has been endemic in the Western Hemisphere and South Pacific, causing outbreaks of dengue fever (DF), but has not been linked to dengue hemorrhagic fever (DHF). The Southeast Asian (SEA) genotype of dengue was introduced into this hemisphere in 1981, has caused outbreaks with numerous cases of DHF, and has displaced the AM genotype in several countries. We investigated the effect of viral genotype on the potential for transmission by infecting Aedes aegypti mosquitoes collected in South Texas with six viruses, representing these two genotypes. Viral replication in the midgut was significantly higher in SEA-infected mosquitoes, and virus-specific proteins could be detected in salivary glands 7 days earlier in SEA- than AM-infected mosquitoes. This much earlier appearance of dengue virus in salivary glands resulted in an estimated 2- to 65-fold increase in the vectorial capacity of these mosquitoes for the viruses that can cause DHF. This may be one of the mechanisms through which more virulent flaviviruses spread and displace others globally.
Indexed as
Identifiers
17123982PMC1993907W2153224565What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.