ArticleJournal of dermatological science2007
Roles for IL-1 and TNFalpha in dynamic behavioral responses of Langerhans cells to topical hapten application.
Article in Journal of dermatological science, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 35 citations in OpenAlex.
- NLRP3 Inflammasome and Allergic Contact Dermatitis: A Connection to Demystify.Pharmaceutics · 2020Review
- Interleukin-1 as Innate Mediator of T Cell Immunity.Frontiers in immunology · 2020Review
- Tri-culture system for pro-hapten sensitizer identification and potency classification.Technology · 2018Article
- Innate immunity and effector and regulatory mechanisms involved in allergic contact dermatitis.Anais brasileiros de dermatologia · 2018Review
- Intravital multiphoton imaging of cutaneous immune responses.The Journal of investigative dermatology · 2014Article
- Perivascular macrophages mediate neutrophil recruitment during bacterial skin infection.Nature immunology · 2014Article
- Mechanisms by which chronic ethanol feeding impairs the migratory capacity of cutaneous dendritic cells.Alcoholism, clinical and experimental research · 2013Article
- Exposure to ionizing radiation induces the migration of cutaneous dendritic cells by a CCR7-dependent mechanism.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Real-time visualization of macromolecule uptake by epidermal Langerhans cells in living animals.The Journal of investigative dermatology · 2012Article
- Epidermal barrier dysfunction and cutaneous sensitization in atopic diseases.The Journal of clinical investigation · 2012Review
- Early immune events in the induction of allergic contact dermatitis.Nature reviews. Immunology · 2012Review
- Intravital multiphoton imaging of immune responses in the mouse ear skin.Nature protocols · 2012Article
- Changes in human Langerhans cells following intradermal injection of influenza virus-like particle vaccines.PloS one · 2010Article
- Influenza virus-like particles coated onto microneedles can elicit stimulatory effects on Langerhans cells in human skin.Vaccine · 2010Article
- External antigen uptake by Langerhans cells with reorganization of epidermal tight junction barriers.The Journal of experimental medicine · 2009Article
- Development of an ex vivo human skin model for intradermal vaccination: tissue viability and Langerhans cell behaviour.Vaccine · 2009Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundTo understand the behavioral biology of Langerhans cells (LCs), we recently recorded time-lapse images of LCs in the knock-in mice expressing the I-Abeta chain tagged with the enhanced green fluorescence protein (EGFP). EGFP(+) LCs showed relatively limited motility in the steady state, whereas topical application of dinitrofluorobenzene (DNFB) markedly augmented a unique movement of dendrites characterized by rhythmic extension and retraction, termed dSEARCH, and triggered amoeba-like lateral migration of cell bodies.
objectiveTo define underlying mechanisms by which hapten treatment alters LC behaviors.
methodsThe I-Abeta-EGFP mice received subcutaneous (s.c.) injection of recombinant IL-1alpha or TNFalpha (50 ng/animal) and dynamic behaviors of EGFP(+) LCs were recorded by time-lapse confocal microscopy at several time points to measure their dSEARCH activities and lateral migration. In a different set of experiments, IL-1 receptor antagonist (IL-1Ra) or soluble TNF receptor-2 (sTNFR2) (0.5 microg/animal) was s.c. injected into the ear skin 30 min before topical application of DNFB, and LC behaviors analyzed 30 h later.
resultsLocal injection of IL-1alpha or TNFalpha induced significant, albeit modest, augmentation of both dSEARCH and lateral migration. Co-injection of TNFalpha and IL-1alpha further exacerbated motile activities in a synergistic manner by similar magnitudes observed after DNFB application. Conversely, DNFB-induced behavioral changes were inhibited completely by local injection of IL-1Ra or sTNFR2.
conclusionIL-1 and TNFalpha serve as equally important mediators of hapten-induced alteration of LC behaviors. Motile activities of epidermal LCs are reprogrammed by selected cytokines known to be produced by keratinocytes under pathological conditions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.