ArticleNeuroscience letters2007
Neurotransmitter depletion by bafilomycin is promoted by vesicle turnover.
Article in Neuroscience letters, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Substrate recognition and allosteric regulation of synaptic vesicle glutamate transporter VGLUT2.Nature structural & molecular biology · 2025Article
- The CHD family chromatin remodeling enzyme, Kismet, promotes both clathrin-mediated and activity-dependent bulk endocytosis.PloS one · 2024Article
- Detection of Glutamate Encapsulated in Liposomes by Optical Trapping Raman Spectroscopy.ACS omega · 2022Article
- The CD63 homologs, Tsp42Ee and Tsp42Eg, restrict endocytosis and promote neurotransmission through differential regulation of synaptic vesicle pools.Frontiers in cellular neuroscience · 2022Article
- Spontaneous, synchronous zinc spikes oscillate with neural excitability and calcium spikes in primary hippocampal neuron culture.Journal of neurochemistry · 2021Article
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- Mechanisms, pools, and sites of spontaneous vesicle release at synapses of rod and cone photoreceptors.The European journal of neuroscience · 2016Article
- The V-ATPase membrane domain is a sensor of granular pH that controls the exocytotic machinery.The Journal of cell biology · 2013Article
- Regenerative glutamate release by presynaptic NMDA receptors contributes to spreading depression.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2013Article
- Channel-mediated astrocytic glutamate release via Bestrophin-1 targets synaptic NMDARs.Molecular brain · 2013Article
- Serotonin and synaptic transmission at invertebrate neuromuscular junctions.Experimental neurobiology · 2012Article
- Synaptic vesicles control the time course of neurotransmitter secretion via a Ca²+/H+ antiport.The Journal of physiology · 2011Article
- Synapsin regulates vesicle organization and activity-dependent recycling at Drosophila motor boutons.Neuroscience · 2010Article
- TGF-beta2 alters the characteristics of the neuromuscular junction by regulating presynaptic quantal size.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Functional anatomical evidence for respiratory rhythmogenic function of endogenous bursters in rat medulla.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Kissing or fused since some time.Frontiers in synaptic neuroscience · 2010Article
- Extrasynaptic release of GABA by retinal dopaminergic neurons.Journal of neurophysiology · 2009Article
- Homeostatic synapse-driven membrane plasticity in nucleus accumbens neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Accumulation of neurotransmitter into synaptic vesicles is powered by the vacuolar proton ATPase. We show here that, in brain slices, application of the H(+)-ATPase inhibitors bafilomycin or concanamycin does not efficiently deplete glutamatergic vesicles of transmitter unless vesicle turnover is increased. Simulations of vesicle energetics suggest either that bafilomycin and concanamycin act on the H(+)-ATPase from inside the vesicle, or that the vesicle membrane potential is maintained after the H(+)-ATPase is inhibited.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.