ArticleGenes and immunity2007
Genome-wide scan for visceral leishmaniasis susceptibility genes in Brazil.
Article in Genes and immunity, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- A systematic literature review on the European, African and Amerindian genetic ancestry components on Brazilian health outcomes.Scientific reports · 2019Pooled it
- Control of visceral leishmaniasis in latin america-a systematic review.PLoS neglected tropical diseases · 2010Pooled it
- Human genetics of leishmania infections.Human genetics · 2020Review
- SLC11A1 (rs3731865) polymorphism and susceptibility to visceral leishmaniasis in HIV-coinfected patients from Northeastern Brazil.Parasitology research · 2020Article
- Epitope-Binding Characteristics for Risk versus Protective DRB1 Alleles for Visceral Leishmaniasis.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Comprehensive candidate gene analysis for symptomatic or asymptomatic outcomes of Leishmania infantum infection in Brazil.Annals of human genetics · 2017Article
- Fine mapping under linkage peaks for symptomatic or asymptomatic outcomes of Leishmania infantum infection in Brazil.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2016Article
- Article
- The role of IL15 gene variants in visceral leishmaniasis among Iranian patients.Molecular biology reports · 2013Article
- Common variants in the HLA-DRB1-HLA-DQA1 HLA class II region are associated with susceptibility to visceral leishmaniasis.Nature genetics · 2013Article
- Influence of genetic variation on plasma protein levels in older adults using a multi-analyte panel.PloS one · 2013Article
- Determinants for the development of visceral leishmaniasis disease.PLoS pathogens · 2013Review
- Genetic and functional evaluation of the role of DLL1 in susceptibility to visceral leishmaniasis in India.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2012Article
- Genetic control of canine leishmaniasis: genome-wide association study and genomic selection analysis.PloS one · 2012Article
- Genetic evidence of functional ficolin-2 haplotype as susceptibility factor in cutaneous leishmaniasis.PloS one · 2012Article
- Genetic and functional evidence implicating DLL1 as the gene that influences susceptibility to visceral leishmaniasis at chromosome 6q27.The Journal of infectious diseases · 2011Article
- Article
- Further evidences on a new diagnostic approach for monitoring human Leishmania (L.) infantum chagasi infection in Amazonian Brazil.Parasitology research · 2010Article
- Genetic admixture in Brazilians exposed to infection with Leishmania chagasi.Annals of human genetics · 2009Article
- Genetics and visceral leishmaniasis: of mice and man.Parasite immunology · 2009Review
Corrections and comments
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Authors and funding
11 authors at 8 institutions in 3 countries.
Funding
Abstract
A genome-wide scan was conducted for visceral leishmaniasis (VL) in Brazil. Initially, 405 markers were typed in 22 multicase pedigrees (28 nuclear families; 174 individuals; 66 affected). Non-parametric multipoint analysis detected nine chromosomal regions with provisional evidence (logarithm of the odds (LOD) scores 0.95-1.66; 0.003<P<0.018) for linkage. To confirm linkage, 132 individuals (43 affected) from 19 independently ascertained families were genotyped across these regions. Three regions (6q27, 7q11.22 and 17q11.2-q21.3) retained evidence (LOD scores 1.08, 1.34, 1.14; P=0.013, 0.007, 0.011) for linkage. To determine which genes contribute to linkage at 17q11.2-q21.3, 80 single nucleotide polymorphisms were genotyped in 98 nuclear families with 183 affected individuals. Family-based association test analysis indicated associations at two chemokine genes, CCL1 and CCL16, that lie 1.6 Mb apart, show some extended linkage disequilibrium with each other, but each lie within different clusters of candidate CCL genes. Multiple genes may therefore contribute to the linkage peak for VL at 17q12.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.