ArticleEukaryotic cell2007
Limited functional redundancy and oscillation of cyclins in multinucleated Ashbya gossypii fungal cells.
Article in Eukaryotic cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 22 citations in OpenAlex.
- RNA-specific local translation is patterned by condensates for multinucleate cell growth.Nature cell biology · 2026Article
- Self-Organization and Information Processing: From Basic Enzymatic Activities to Complex Adaptive Cellular Behavior.Frontiers in genetics · 2021Review
- Comprehensive Analysis of G1 Cyclin Docking Motif Sequences that Control CDK Regulatory Potency In Vivo.Current biology : CB · 2020Article
- Cyclins in aspergilli: Phylogenetic and functional analyses of group I cyclins.Studies in mycology · 2018Article
- Clustered nuclei maintain autonomy and nucleocytoplasmic ratio control in a syncytium.Molecular biology of the cell · 2016Article
- Nuclear autonomy in multinucleate fungi.Current opinion in microbiology · 2015Review
- A docking interface in the cyclin Cln2 promotes multi-site phosphorylation of substrates and timely cell-cycle entry.Current biology : CB · 2015Article
- Elements of the cellular metabolic structure.Frontiers in molecular biosciences · 2015Article
- Article
- Evolution of networks and sequences in eukaryotic cell cycle control.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2011Review
- The metabolic core and catalytic switches are fundamental elements in the self-regulation of the systemic metabolic structure of cells.PloS one · 2011Article
- Controlled chaos: new insights into genetically programmed cell cycle asynchrony.Cell cycle (Georgetown, Tex.) · 2010Article
- Quantitative analysis of cellular metabolic dissipative, self-organized structures.International journal of molecular sciences · 2010Review
- A conserved G₁ regulatory circuit promotes asynchronous behavior of nuclei sharing a common cytoplasm.Cell cycle (Georgetown, Tex.) · 2010Article
- Global self-regulation of the cellular metabolic structure.PloS one · 2010Article
- Article
- Differential selection on gene translation efficiency between the filamentous fungus Ashbya gossypii and yeasts.BMC evolutionary biology · 2008Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cyclin protein behavior has not been systematically investigated in multinucleated cells with asynchronous mitoses. Cyclins are canonical oscillating cell cycle proteins, but it is unclear how fluctuating protein gradients can be established in multinucleated cells where nuclei in different stages of the division cycle share the cytoplasm. Previous work in A. gossypii, a filamentous fungus in which nuclei divide asynchronously in a common cytoplasm, demonstrated that one G1 and one B-type cyclin do not fluctuate in abundance across the division cycle. We have undertaken a comprehensive analysis of all G1 and B-type cyclins in A. gossypii to determine whether any of the cyclins show periodic abundance across the cell cycle and to examine whether cyclins exhibit functional redundancy in such a cellular environment. We localized all G1 and B-type cyclins and notably found that only AgClb5/6p varies in subcellular localization during the division cycle. AgClb5/6p is lost from nuclei at the meta-anaphase transition in a D-box-dependent manner. These data demonstrate that efficient nuclear autonomous protein degradation can occur within multinucleated cells residing in a common cytoplasm. We have shown that three of the five cyclins in A. gossypii are essential genes, indicating that there is minimal functional redundancy in this multinucleated system. In addition, we have identified a cyclin, AgClb3/4p, that is essential only for sporulation. We propose that the cohabitation of different cyclins in nuclei has led to enhanced substrate specificity and limited functional redundancy within classes of cyclins in multinucleated cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.