ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
Ca2+ dynamics along identified synaptic terminals in Drosophila larvae.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 76 citations in OpenAlex.
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- Postsynaptic Calcium Extrusion at the Mouse Neuromuscular Junction Alkalinizes the Synaptic Cleft.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
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- The CD63 homologs, Tsp42Ee and Tsp42Eg, restrict endocytosis and promote neurotransmission through differential regulation of synaptic vesicle pools.Frontiers in cellular neuroscience · 2022Article
- Computational modeling predicts ephemeral acidic microdomains in the glutamatergic synaptic cleft.Biophysical journal · 2021Article
- Separation of presynaptic CaProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Golgi-Dependent Copper Homeostasis Sustains Synaptic Development and Mitochondrial Content.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Neuronal Glutamatergic Synaptic Clefts Alkalinize Rather Than Acidify during Neurotransmission.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Synaptic Properties and Plasticity Mechanisms of Invertebrate Tonic and Phasic Neurons.Frontiers in physiology · 2020Review
- Review
- cindr, the Drosophila Homolog of the CD2AP Alzheimer's Disease Risk Gene, Is Required for Synaptic Transmission and Proteostasis.Cell reports · 2019Article
- Inter-relationships among physical dimensions, distal-proximal rank orders, and basal GCaMP fluorescence levels in CaJournal of neurogenetics · 2018Article
- The application of 'kisser' probes for resolving the distribution and microenvironment of membrane proteins in situ.Journal of neurogenetics · 2018Article
- 3D-QSAR and Molecular Docking Studies on the TcPMCA1-Mediated Detoxification of Scopoletin and Coumarin Derivatives.International journal of molecular sciences · 2017Article
- Synaptic neuropeptide release by dynamin-dependent partial release from circulating vesicles.Molecular biology of the cell · 2015Article
- BMP signaling and microtubule organization regulate synaptic strength.Neuroscience · 2015Article
- Synaptic excitation is regulated by the postsynaptic dSK channel at the Drosophila larval NMJ.Journal of neurophysiology · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Changes in intracellular Ca2+ concentration ([Ca2+]i) play an important role in the function and plasticity of synapses. We characterized the changes in [Ca2+]i produced by action potentials (APs) along two identified motor terminals found on separate muscle fibers in Drosophila larvae and examined factors that influence the amplitude and duration of the residual Ca2+ signal. We were able to measure Ca2+ transients produced along terminals by both single APs and AP trains using Oregon Green 488 BAPTA-1 and streaming images at 20-50 Hz. The decay of [Ca2+]i after single APs or AP trains was well fit by a single exponential. For single APs, the Ca2+ transient amplitude and decay rate were similar at boutons and bottleneck regions and much smaller at the axon. Also, the amplitude of single-AP Ca2+ transients was inversely correlated with bouton width. During AP trains, the increase in [Ca2+]i became more uniform: the difference in boutons and axons was reduced, and the increase in [Ca2+]i was not correlated with bouton width. The [Ca2+]i decay tau was directly correlated with bouton width for both single APs and AP trains. For one terminal, distal boutons had larger single-AP Ca2+ transients than proximal ones, probably attributable to greater Ca2+ influx for distal boutons. Pharmacological studies showed that Ca2+ clearance from these synaptic terminals after single APs and AP trains was primarily attributable to Ca2+ extrusion by the plasma membrane Ca2+ ATPase (PMCA). Immunostaining of larval muscle fibers showed high levels of the PMCA at the neuromuscular junction.
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