ArticleProceedings of the National Academy of Sciences of the United States of America2006
Activation of an oncogenic microRNA cistron by provirus integration.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 67 citations in OpenAlex.
- MicroRNAs and long non-coding RNAs during transcriptional regulation and latency of HIV and HTLV.Retrovirology · 2024Review
- Clinical and biological impact of miR-18a expression in breast cancer after neoadjuvant chemotherapy.Cellular oncology (Dordrecht, Netherlands) · 2019Article
- Overexpression of miR-21-5p promotes proliferation and invasion of colon adenocarcinoma cells through targeting CHL1.Molecular medicine (Cambridge, Mass.) · 2018Article
- Decreased MiR-17 in glioma cells increased cell viability and migration by increasing the expression of Cyclin D1, p-Akt and Akt.PloS one · 2018Article
- The miR-106a~363Oncotarget · 2017Article
- Insertional hypermutation in mineral oil-induced plasmacytomas.European journal of immunology · 2014Article
- MicroRNAs, genomic instability and cancer.International journal of molecular sciences · 2014Review
- Novel principles of gamma-retroviral insertional transcription activation in murine leukemia virus-induced end-stage tumors.Retrovirology · 2014Article
- The miR-17/92 cluster: a comprehensive update on its genomics, genetics, functions and increasingly important and numerous roles in health and disease.Cell death and differentiation · 2013Review
- MicroRNA-18a attenuates DNA damage repair through suppressing the expression of ataxia telangiectasia mutated in colorectal cancer.PloS one · 2013Article
- MicroRNA-200 is commonly repressed in conjunctival MALT lymphoma, and targets cyclin E2.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2012Article
- Article
- Genomic instability and mouse microRNAs.Toxicology mechanisms and methods · 2011Review
- Regulation of endoderm formation and left-right asymmetry by miR-92 during early zebrafish development.Development (Cambridge, England) · 2011Article
- mir-17-92, a cluster of miRNAs in the midst of the cancer network.The international journal of biochemistry & cell biology · 2010Review
- A retroviral mutagenesis screen identifies Cd74 as a common insertion site in murine B-lymphomas and reveals the existence of a novel IFNgamma-inducible Cd74 isoform.Molecular cancer · 2010Article
- Article
- Tumorigenicity of the miR-17-92 cluster distilled.Genes & development · 2010Article
- Non-cell-autonomous effects of vector-expressed regulatory RNAs in mammalian heart cells.Gene therapy · 2009Article
- Loss of MicroRNA targets in the 3' untranslated region as a mechanism of retroviral insertional activation of growth factor independence 1.Journal of virology · 2009Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Retroviruses can cause tumors when they integrate near a protooncogene or tumor suppressor gene of the host. We infected >2,500 mice with the SL3-3 murine leukemia virus; in 22 resulting tumors, we found provirus integrations nearby or within the gene that contains the mir-17-92 microRNA (miRNA) cistron. Using quantitative real-time PCR, we showed that expression of miRNA was increased in these tumors, indicating that retroviral infection can induce expression of oncogenic miRNAs. Our results demonstrate that retroviral mutagenesis can be a potent tool for miRNA discovery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.