ArticleThorax2007
Multilocus analysis of atopy in Korean children using multifactor-dimensionality reduction.
Article in Thorax, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- Clinical Characteristics and Genetic Variations in Early-Onset Atopic Dermatitis Patients.Annals of dermatology · 2019Article
- Differences in Genetic Variations Between Treatable and Recalcitrant Atopic Dermatitis in Korean.Allergy, asthma & immunology research · 2018Article
- Association of the rs2071559 (T/C) polymorphism with lymphatic metastasis in patients with nasopharyngeal carcinoma.Oncology letters · 2017Article
- Transdisciplinary approaches enhance the production of translational knowledge.Translational research : the journal of laboratory and clinical medicine · 2017Review
- Bridging the gap between statistical and biological epistasis in Alzheimer's disease.BioMed research international · 2015Review
- Genetics of Alzheimer's disease.BioMed research international · 2013Review
- Common polymorphisms in angiogenesis.Cold Spring Harbor perspectives in medicine · 2012Review
- Multifactor dimensionality reduction as a filter-based approach for genome wide association studies.Frontiers in genetics · 2011Article
- Past, present, and future of allergy in Korea.Allergy, asthma & immunology research · 2010Article
- Association of the VEGFR2 gene His472Gln polymorphism with endurance-related phenotypes.European journal of applied physiology · 2009Article
- Association of four-locus gene interaction with aspirin-intolerant asthma in Korean asthmatics.Journal of clinical immunology · 2008Article
- Looking for a bit of co-action?Thorax · 2007Article
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAtopy is considered to be a complex genetic trait and does not follow a simple mendelian pattern of inheritance. It is now well recognised that gene-gene interactions are important in complex genetic disease.
aimTo analyse the influence of gene-gene interactions in the development of atopy.
methodsA total of 2055 ethnically identical participants aged 10-18 years living in rural areas on Jeju Island, Korea, were randomly recruited. Atopy was defined as a positive skin prick test response to one or more common inhalant allergens. Gene-gene interactions among 12 polymorphic loci were analysed in the seven candidate genes of atopy using the multidimensionality-reduction method.
resultsA significant interaction was found between V297I in the gene coding vascular endothelial growth factor receptor 2 (KDR) and -308G-->A in the gene coding tumour necrosis factor (TNF)alpha on the risk of atopy, with a cross-validation consistency of 10 out of 10 and a prediction error of 35.9% (p = 0.001). Conventional logistic regression also revealed significant interactions between KDR and TNF for atopy. Individuals with the variant allele of -308G-->A in TNF (GA or AA) and V297I in KDR (VI or II) had a significantly higher risk of atopy (OR 2.23; 95% CI 1.48 to 3.57).
conclusionKDR and TNF may synergistically influence the development of atopy through gene-gene interaction in Korean children and adolescents.
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