ReviewBioEssays : news and reviews in molecular, cellular and developmental biology2006
The molecular basis of neurosensory cell formation in ear development: a blueprint for hair cell and sensory neuron regeneration?
Review in BioEssays : news and reviews in molecular, cellular and developmental biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
67 citing papers in PubMed.
- A dual-organ genetic interplay between sensorineural hearing loss and kidney disease: an update for clinicians.Pediatric nephrology (Berlin, Germany) · 2026Review
- Exploring delivery systems for targeted nanotechnology-based gene therapy in the inner ear.Therapeutic delivery · 2024Review
- Gata3 is required in late proneurosensory development for proper sensory cell formation and organization.Scientific reports · 2023Article
- Gata3 is Required in Late Proneurosensory Development for Proper Sensory Cell Formation and Organization.Research square · 2023Article
- Age-Related Hearing Loss: Sensory and Neural Etiology and Their Interdependence.Frontiers in aging neuroscience · 2022Review
- Development in the Mammalian Auditory System Depends on Transcription Factors.International journal of molecular sciences · 2021Review
- Embryology, Malformations, and Rare Diseases of the Cochlea.Laryngo- rhino- otologie · 2021Article
- Trk agonist drugs rescue noise-induced hidden hearing loss.JCI insight · 2021Article
- Using Sox2 to alleviate the hallmarks of age-related hearing loss.Ageing research reviews · 2020Review
- GSK3 regulates hair cell fate in the developing mammalian cochlea.Developmental biology · 2019Article
- Understanding Molecular Evolution and Development of the Organ of Corti Can Provide Clues for Hearing Restoration.Integrative and comparative biology · 2018Article
- Hearing crosstalk: the molecular conversation orchestrating inner ear dorsoventral patterning.Wiley interdisciplinary reviews. Developmental biology · 2018Review
- Gene, cell, and organ multiplication drives inner ear evolution.Developmental biology · 2017Review
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- Signaling and Transcription Factors during Inner Ear Development: The Generation of Hair Cells and Otic Neurons.Frontiers in cell and developmental biology · 2017Article
- The Repression of Atoh1 by Neurogenin1 during Inner Ear Development.Frontiers in molecular neuroscience · 2017Article
- Advances in nano-based inner ear delivery systems for the treatment of sensorineural hearing loss.Advanced drug delivery reviews · 2017Review
- Deterioration of the Medial Olivocochlear Efferent System Accelerates Age-Related Hearing Loss in Pax2-Isl1 Transgenic Mice.Molecular neurobiology · 2016Article
- Insm1 promotes neurogenic proliferation in delaminated otic progenitors.Mechanisms of development · 2015Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The inner ear of mammals uses neurosensory cells derived from the embryonic ear for mechanoelectric transduction of vestibular and auditory stimuli (the hair cells) and conducts this information to the brain via sensory neurons. As with most other neurons of mammals, lost hair cells and sensory neurons are not spontaneously replaced and result instead in age-dependent progressive hearing loss. We review the molecular basis of neurosensory development in the mouse ear to provide a blueprint for possible enhancement of therapeutically useful transformation of stem cells into lost neurosensory cells. We identify several readily available adult sources of stem cells that express, like the ectoderm-derived ear, genes known to be essential for ear development. Use of these stem cells combined with molecular insights into neurosensory cell specification and proliferation regulation of the ear, might allow for neurosensory regeneration of mammalian ears in the near future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.