ArticleJournal of neuro-oncology2007
Epidemiological survey of central nervous system germ cell tumors in Canadian children.
Article in Journal of neuro-oncology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 85 citations in OpenAlex.
- Central nervous system germ cell tumor, an archetypal AYA tumor and a model for pediatric and neuro-oncology collaboration, review from the EURACAN domain 10 group.Frontiers in oncology · 2022Pooled it
- Intracranial Germ Cell Tumors: An Updated Review of Diagnostic Strategies and Treatment Paradigms.Asian journal of neurosurgery · 2026Review
- Germinomas and Non-germinomatous Germ Cell Tumors.Advances and technical standards in neurosurgery · 2026Review
- Simultaneous occurrence of bilateral retroperitoneal neuroblastoma and bifocal malignant mixed germ cell tumor in a pediatric patient with 16p11.2 microdeletion syndrome: a case report.Frontiers in endocrinology · 2025Article
- Prognostic factors of pediatric pineal region tumors at a single institution.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Article
- Intracranial Germinoma-Association between Delayed Diagnosis, Altered Clinical Manifestations, and Prognosis.Cancers · 2023Article
- Brain and Spinal Tumors Originating from the Germ Line Cells.Advances in experimental medicine and biology · 2023Article
- De-differentiated metastatic adenosquamous carcinoma arising from germ cell tumor in the brain and spine.Acta neurochirurgica · 2022Article
- Hypothalamic syndrome.Nature reviews. Disease primers · 2022Review
- Essential Management of Pediatric Brain Tumors.Children (Basel, Switzerland) · 2022Review
- EANO, SNO and Euracan consensus review on the current management and future development of intracranial germ cell tumors in adolescents and young adults.Neuro-oncology · 2022Article
- Clinical Outcomes and Diagnostic Consistency of Serum and CSF Tumor Markers in Pediatric Intracranial Germ Cell Tumors in Thailand: A Multicenter Study.Global pediatric health · 2022Article
- Canadian Pediatric Neuro-Oncology Standards of Practice.Frontiers in oncology · 2020Article
- Comprehensive Evaluation of Rare Pituitary Lesions: A Single Tertiary Care Pituitary Center Experience and Review of the Literature.Endocrine pathology · 2019Review
- Neurocognitive function, performance status, and quality of life in pediatric intracranial germ cell tumor survivors.Journal of neuro-oncology · 2019Article
- Nationwide Population-Based Incidence and Survival Rates of Malignant Central Nervous System Germ Cell Tumors in Korea, 2005-2012.Cancer research and treatment · 2017Article
- Intracranial germ cell tumors: a multi-institutional experience from three tertiary care centers in India.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2016Article
- Utility of MRI versus tumor markers for post-treatment surveillance of marker-positive CNS germ cell tumors.Journal of neuro-oncology · 2016Article
- Article
- Outcomes of children with central nervous system germinoma treated with multi-agent chemotherapy followed by reduced radiation.Journal of neuro-oncology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 16 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo determine the incidence and characteristics of pediatric patients with central nervous system (CNS) germ cell tumors (GCT) in Canada.
methodA national retrospective review of hospital charts was done on all patients with CNS GCT diagnosed between 1990 and 2004. Patients had to be under age 18 years at the time of diagnosis of a CNS germ cell tumor and be a resident of Canada. Information extracted included age and year of diagnosis, pathological diagnosis, location of tumor, evidence of disseminated disease at time of diagnosis and biological markers.
resultsOne hundred and twenty-one cases were identified (83 germinoma; 38 non-germinoma germ cell tumor). The mean annual incidence of CNS GCT was 1.06 per million children (0.7 per million for germinoma; 0.3 per million for NGGCT). Though yearly incidences varied, there was no clear trend to increased incidence. Male predominance was noted (2.4:1 for germinoma; 11:1 for NGGCT). The primary locations were the pineal and suprasellar regions. At the time of diagnosis, disseminated disease was not uncommon (22% germinoma; 32% NGGCT). Beta human gonadotrophin was elevated in the serum, cerebrospinal fluid (CSF) or both in 7% of patients with germinoma and 36% of patients with NGGCT. Elevation of alpha-fetoprotein in serum, CSF or both was seen in 34% of patients with NGGCT.
conclusionThe incidence of CNS germ cell tumors in Canadian children is similar to that observed in other Western countries.
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Registered trials
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