ArticleHuman genetics2007
Contributions of the DAT1 and DRD2 genes to serious and violent delinquency among adolescents and young adults.
Article in Human genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 3 of them syntheses that pooled it.
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Who cites it
47 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Dopamine genes are linked to Extraversion and Neuroticism personality traits, but only in demanding climates.Scientific reports · 2018Pooled it
- Multicenter analysis of the SLC6A3/DAT1 VNTR haplotype in persistent ADHD suggests differential involvement of the gene in childhood and persistent ADHD.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2010Pooled it
- Pooled it
- Dopamine modulation of aggression.Psychopharmacology · 2026Review
- Positive Selection in Aggression-Linked Genes and Their Protein Interaction Networks.Life (Basel, Switzerland) · 2025Article
- Parental incarceration in childhood and violent delinquent behaviors in adulthood: Race/ethnicity and sex differences.Journal of family trauma, child custody & child development · 2024Article
- Early childhood psychosocial family risks and cumulative dopaminergic sensitizing score: Links to behavior problems in U.S. 9-year-olds.Journal of affective disorders · 2021Article
- The Interaction of Dopamine Genes and Financial Stressors to Predict Adulthood Intimate Partner Violence Perpetration.Journal of interpersonal violence · 2020Article
- Describing associations between child maltreatment frequency and the frequency and timing of subsequent delinquent or criminal behaviors across development: variation by sex, sexual orientation, and race.BMC public health · 2019Article
- Emotional stability is associated with the MAOA promoter uVNTR polymorphism in women.Brain and behavior · 2019Article
- Disrupting the link between maltreatment and delinquency: how school, family, and community factors can be protective.BMC public health · 2019Article
- Loss of Primary Cilia Results in the Development of Cancer in the Murine Thyroid Gland.Molecules and cells · 2019Article
- Article
- The interaction between monoamine oxidase A and punitive discipline in the development of antisocial behavior: Mediation by maladaptive social information processing.Development and psychopathology · 2017Article
- Gene-Gene-Environment Interactions of Serotonin Transporter, Monoamine Oxidase A and Childhood Maltreatment Predict Aggressive Behavior in Chinese Adolescents.Frontiers in behavioral neuroscience · 2017Article
- Article
- Interactions of adolescent social experiences and dopamine genes to predict physical intimate partner violence perpetration.PloS one · 2017Article
- Reciprocal moderation byPteridines · 2016Article
- Looking for reward in all the wrong places: dopamine receptor gene polymorphisms indirectly affect aggression through sensation-seeking.Social neuroscience · 2016Article
- Article
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3 authors.
Funding
Abstract
As far as we know, this is the first national study that reports compelling evidence for the main effects of genetic variants on serious and violent delinquency among adolescents and young adults. This study investigated the association between the self-reported serious and violent delinquency and the TaqI polymorphism in the DRD2 gene and the 40-bp VNTR in the DAT1 gene. The study was based on a cohort of more than 2,500 adolescents and young adults in the National Longitudinal Study of Adolescent Health in the United States. The trajectories of serious delinquency for the DAT1*10R/10R and DAT1*10R/9R genotypes are about twice as high as that for the DAT1*9R/9R genotype (LR test, P = 0.018, 2 df). For DRD2, the trajectory of serious delinquency for the heterozygotes (A1/A2) is about 20% higher than the A2/A2 genotype and about twice as high as the A1/A1 genotype, a phenomenon sometimes described as heterosis (LR test, P = 0.005, 2 df). The findings on violent delinquency closely resemble those on serious delinquency. The trajectories of violent delinquency for the DAT1*10R/9R and DAT1*10R/10R genotype are again about twice as high as that for DAT1*9R/9R (LR test, P = 0.021, 2 df). The two homozygotes of DRD2*A1/A1 and DRD2*A2/A2 scored lower (LR test, P = 0.0016, 2 df) than the heterozygotes. The findings in the models that consider DAT1 and DRD2 jointly (serious delinquency P = 0.0016, 4 df; violent delinquency P = 0.0006, 4 df) are essentially the same as those in the single-gene models, suggesting the absence of a significant correlation between the two genetic variants. These results only apply to males. Neither variant is associated with delinquency among females.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.