ArticleEuropean journal of pediatrics2007
Massive gastrointestinal haemorrhage in isolated intestinal Henoch-Schonlein purpura with response to intravenous immunoglobulin infusion.
Article in European journal of pediatrics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Guidelines for the diagnosis and management of childhood immunoglobulin A vasculitis.World journal of pediatrics : WJP · 2025Guideline
- [Clinical effect of gamma globulin pulse therapy for abdominal Henoch-Schönlein purpura in children].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2016Trial
- Clinical practice guideline for pediatric IgA vasculitis in Japan 2023: a digest-secondary publication.Clinical and experimental nephrology · 2026Review
- Review
- Review
- Intravenous immunoglobulin therapy in immunoglobulin A vasculitis with gastrointestinal tract involvement.Clinical and experimental medicine · 2023Article
- Hemoperfusion and intravenous immunoglobulins for refractory gastrointestinal involvement in pediatric Henoch-Schönlein purpura: a single-center retrospective cohort study.BMC pediatrics · 2022Article
- Massive Intestinal Bleeding in an Adult with IgA Vasculitis Treated with Intravenous Immunoglobulin.Case reports in rheumatology · 2022Article
- Henoch-Schönlein Purpura-Associated Hemorrhagic Shock After Secondary Norovirus Infection.Cureus · 2020Article
- IntravenousCase reports in pediatrics · 2020Article
- Intravenous immunoglobulin in Henoch-Schönlein purpura complicated by cerebral hemorrhage.Rheumatology international · 2013Article
- Henoch-Schönlein purpura: a clinical case with dramatic presentation.BMJ case reports · 2010Article
- Childhood cutaneous vasculitis: a comprehensive appraisal.Indian journal of dermatology · 2009Article
- Non-ST Elevation Myocardial Infraction after High Dose Intravenous Immunoglobulin Infusion.Case reports in medicine · 2009Article
- Leukocytapheresis for the treatment of refractory Henoch-Schönlein purpura resistant to both prednisolone and intravenous immunoglobulin therapy.Rheumatology international · 2008Article
- Leukocytapheresis for the treatment of refractory Henoch-Schönlein purpura resistant to both prednisolone and intravenous immunoglobulin therapy.Rheumatology international · 2008Article
- Severe gastrointestinal vasculitis in Henoch-Schoenlein purpura: pathophysiologic mechanisms, the diagnostic value of factor XIII, and therapeutic options.European journal of pediatrics · 2007Article
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Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is increasing recognition that Henoch-Schonlein purpura may present in an atypical form in which gastrointestinal symptoms may predominate, and classic cutaneous changes may be delayed or absent. This may lead to significant diagnostic delay. We report the case of a 9-year-old girl who presented acutely with life-threatening gastrointestinal haemorrhage from multiple intestinal sites, with no skin rash and only mild evidence of renal involvement. Henoch-Schonlein purpura was confirmed by finding IgA deposition on vessels within gastric and duodenal mucosa, while immunohistochemistry also identified dense focal T cell infiltration in gastric mucosa and within duodenal epithelium. After initial stabilisation, the patient became shocked due to further gastrointestinal haemorrhage. Isotope bleeding scan identified multiple bleeding sites. Her endoscopically confirmed gastritis was sufficiently severe to preclude corticosteroids, and she was thus treated with intravenous immunoglobulin. This therapy induced prompt and sustained resolution of symptoms, and she has remained well since. Our patient's response concords with previous reports in corticosteroid-resistant cases to suggest that severe intestinal Henoch-Schonlein purpura may respond preferentially to intravenous immunoglobulin (IVIG) therapy. In severe cases where there is significant gastritis, IVIG provides an effective alternative to corticosteroids that may be employed as first-line therapy.
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