ArticleEuropean journal of pediatrics2007
Adjunctive treatment of disseminated Mycobacterium avium complex infection with interferon alpha-2b in a patient with complete interferon-gamma receptor R1 deficiency.
Article in European journal of pediatrics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 43 citations in OpenAlex.
- Characteristics of Mycobacterial, COVID-19, and Talaromyces Marneffei Infections in Patients with IL12RB1 and IFNGR1 Mutations in Western China.Journal of clinical immunology · 2026Article
- Overcoming Treatment Challenges in HIV-Associated Mycobacterial Diseases: New Therapeutic Frontiers.International journal of molecular sciences · 2025Review
- Interferon Alpha Therapy in MSMD.Journal of clinical immunology · 2024Article
- Role of Type I Interferons duringBiomolecules · 2024Review
- Pathogenicity of Type I Interferons inInternational journal of molecular sciences · 2023Review
- Article
- Context Is Key: Delineating the Unique Functions of IFNα and IFNβ in Disease.Frontiers in immunology · 2020Review
- Type I interferons in host defence and inflammatory diseases.Lupus science & medicine · 2019Review
- The value of transcriptomics in advancing knowledge of the immune response and diagnosis in tuberculosis.Nature immunology · 2018Review
- Type I interferons in tuberculosis: Foe and occasionally friend.The Journal of experimental medicine · 2018Review
- Type I Interferons in the Pathogenesis of Tuberculosis: Molecular Drivers and Immunological Consequences.Frontiers in immunology · 2017Review
- Type I IFN Inhibits Alternative Macrophage Activation during Mycobacterium tuberculosis Infection and Leads to Enhanced Protection in the Absence of IFN-γ Signaling.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Deletion of the entire interferon-γ receptor 1 gene causing complete deficiency in three related patients.Journal of clinical immunology · 2016Article
- '"Why me, why now?" Using clinical immunology and epidemiology to explain who gets nontuberculous mycobacterial infection.BMC medicine · 2016Review
- Mendelian susceptibility to mycobacterial disease: genetic, immunological, and clinical features of inborn errors of IFN-γ immunity.Seminars in immunology · 2014Review
- Infections caused by non-tuberculous mycobacteria in recipients of hematopoietic stem cell transplantation.Frontiers in oncology · 2014Review
- Interferon alpha treatment of patients with impaired interferon gamma signaling.Journal of clinical immunology · 2013Article
- Pattern recognition receptors and cytokines in Mycobacterium tuberculosis infection--the double-edged sword?BioMed research international · 2013Review
- Dynamic roles of type I and type II IFNs in early infection with Mycobacterium tuberculosis.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Mycobacterium tuberculosis and TLR2 agonists inhibit induction of type I IFN and class I MHC antigen cross processing by TLR9.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
We report adjunct treatment of (interferon) IFN-alpha2b (Intron-A) in a patient with complete interferon-gamma receptor R1 (IFNGR1) deficiency suffering from disseminated infection with Mycobacterium avium complex (MAC) resistant to multiple anti-mycobacterial agents. A low dose of IFN-alpha2b (3 x 10(6) units/m(2) three times weekly subcutaneously) successfully attenuated progressive hepatosplenomegaly and abdominal/retroperitoneal/pelvic lymphadenopathy, although the patient continued to be mycobacteremic. This is the first report of a complete IFNGR1 deficiency treated with adjuvant IFN-alpha2b for disseminated MAC infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.