ArticleNeurochemistry international2007
Effects of melatonin and age on gene expression in mouse CNS using microarray analysis.
Article in Neurochemistry international, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 44 citations in OpenAlex.
- Protective Effects of Exogenous Melatonin Administration on White Fat Metabolism Disruption Induced by Aging and a High-Fat Diet in Mice.Antioxidants (Basel, Switzerland) · 2024Article
- Age-Related Effects of Exogenous Melatonin on Anxiety-like Behavior in C57/B6J Mice.Biomedicines · 2023Article
- Gene Expression Changes of Murine Cortex Homeostasis in Response to Sleep Deprivation Hint Dysregulated Aging-like Transcriptional Responses.Brain sciences · 2022Article
- α-Arrestins and Their Functions: From Yeast to Human Health.International journal of molecular sciences · 2022Review
- PDK4 Inhibition Ameliorates Melatonin Therapy by Modulating Cerebral Metabolism and Remyelination in an EAE Demyelinating Mouse Model of Multiple Sclerosis.Frontiers in immunology · 2022Article
- Atrazine Inhalation Causes Neuroinflammation, Apoptosis and Accelerating Brain Aging.International journal of molecular sciences · 2021Article
- Attenuation of acute and chronic inflammation using compounds derived from plants.Experimental biology and medicine (Maywood, N.J.) · 2021Review
- Loss of C/EBPδ Exacerbates Radiation-Induced Cognitive Decline in Aged Mice due to Impaired Oxidative Stress Response.International journal of molecular sciences · 2019Article
- Melatonin Therapy Modulates Cerebral Metabolism and Enhances Remyelination by Increasing PDK4 in a Mouse Model of Multiple Sclerosis.Frontiers in pharmacology · 2019Article
- Mechanisms Underlying Tumor Suppressive Properties of Melatonin.International journal of molecular sciences · 2018Review
- Melatonin antiproliferative effects require active mitochondrial function in embryonal carcinoma cells.Oncotarget · 2015Article
- Circadian System and Melatonin Hormone: Risk Factors for Complications during Pregnancy.Obstetrics and gynecology international · 2015Review
- Age-related differences in the response of the brain to dietary melatonin.Age (Dordrecht, Netherlands) · 2014Article
- Does melatonin ameliorate neurological changes associated with Alzheimer's disease in ovariectomized rat model?Indian journal of clinical biochemistry : IJCB · 2013Article
- Article
- Age-related Purkinje cell death is steroid dependent: RORα haplo-insufficiency impairs plasma and cerebellar steroids and Purkinje cell survival.Age (Dordrecht, Netherlands) · 2011Article
- Nanoparticles and colloids as contributing factors in neurodegenerative disease.International journal of environmental research and public health · 2011Review
- The effects of aging vs. α7 nAChR subunit deficiency on the mouse brain transcriptome: aging beats the deficiency.Age (Dordrecht, Netherlands) · 2011Article
- Extended exposure to dietary melatonin reduces tumor number and size in aged male mice.Experimental gerontology · 2011Article
- The neurotoxicity of environmental aluminum is still an issue.Neurotoxicology · 2010Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The expression levels of a number of genes associated with inflammation and immune function change with advancing age. Melatonin modulates gene expression levels of several of these genes. Therefore the declining levels of melatonin associated with age may play a role in the physiological effects of aging. We used oligonucleotide microarrays to measure age-related changes in mRNA expression in the murine CNS, and to study the effect of prolonged administration of dietary melatonin upon these changes. CB6F1 male mice were fed 40 ppm melatonin for 2.1 months prior to sacrifice at age 26.5 months, and compared with both age-matched controls and young, 4.5-month-old untreated controls. Total RNA was extracted from whole brain (excluding cerebellum and brain stem) and individual samples were hybridized to Affymetrix Mouse 430-2.0 arrays. The expression of a substantial number of genes was modulated by melatonin treatment and changes in selected genes were validated by quantitative reverse transcription polymerase chain reaction (qRT-PCR). A subset of these genes did not change with age. Conversely, some genes modulated by age were also modulated by melatonin treatment. In general, melatonin treatment drove the expression levels of these genes closer to the expression levels detected in the younger animals. Notably, the abundance of lipocalin 2 (Lcn2) mRNA increased with age and was decreased in old animals treated with melatonin. Lcn2 is a member of the acute phase response family of proteins and its mRNA levels in the brain increase in response to inflammation. Many of the genes with expression reduced by melatonin are involved in inflammation and the immune system. This suggests that melatonin treatment may influence the inflammatory responses of old animals, driving them to resemble more closely those occurring in young animals.
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Registered trials
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