Evidence map›Paper›PMID 17118357›Full record

ArticleExperimental parasitology2007

Plasmodium falciparum: immunization with MSP1-42 induced non-inhibitory antibodies that have no blocking activities but enhanced the potency of inhibitory anti-MSP1-42 antibodies.

Mark Nagata, Teri Wong, David Clements, George Hui

Open access · greenAbstract read
In one paragraph

Article in Experimental parasitology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 86% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Mark NagataDepartment of Tropical Medicine and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96813, USA.
Teri Wong
David Clements
George Hui
Hawaii Biotech (United States) · USUniversity of Hawaiʻi at Mānoa · US

Funding

Development of a MSP1-p42 Subunit Vaccine for MalariaR44AI043119 · NIAID · HAWAII BIOTECH, INC. · PI CLEMENTS, DAVID E. · 2001 to 2003
$1.3M
Immune Pathways as Prerequisites for Adjuvants'EfficacyR01AI045768 · NIAID · UNIVERSITY OF HAWAII AT MANOA · PI HUI, GEORGE S · 2001 to 2004
$1.0M
NIAID NIH HHS R01 AI045768NIAID NIH HHS R01AI457680NIAID NIH HHS R44 AI043119NIAID NIH HHS R44AI043119
6 · The paper itself

Abstract

Hyperimmunization with Plasmodium falciparum MSP1-42 could induce antibodies that have little or no parasite growth inhibitory activities. These antisera had no blocking activities as determined by their ability to interfere with the in vitro activities of growth inhibitory anti-MSP1-42 sera. Equally important, they enhanced the potency of growth inhibitory anti-MSP1-42 sera.

Indexed as

AnimalsAntibodies, BlockingAntibodies, ProtozoanEnzyme-Linked Immunosorbent AssayHumansImmune SeraImmunoglobulin GMerozoite Surface Protein 1Plasmodium falciparumRabbitsAntibodies, BlockingAntibodies, ProtozoanImmune SeraImmunoglobulin GMerozoite Surface Protein 1

Identifiers

PMID17118357
PMCPMC1857355
OpenAlexW2095006359

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.