ArticleNucleic acids research1991
A gene encoding 22 highly related zinc fingers is expressed in lymphoid cell lines.
Article in Nucleic acids research, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 31 citations in OpenAlex.
- Gene expression signatures and response to imatinib mesylate in gastrointestinal stromal tumor.Molecular cancer therapeutics · 2009Trial
- Identification of necroptosis genes and characterization of immune infiltration in non-alcoholic steatohepatitis.Hereditas · 2024Article
- Expression of ZNF695 Transcript Variants in Childhood B-Cell Acute Lymphoblastic Leukemia.Genes · 2019Article
- ZNF418, a novel human KRAB/C2H2 zinc finger protein, suppresses MAPK signaling pathway.Molecular and cellular biochemistry · 2008Article
- Evolutionary expansion and divergence in the ZNF91 subfamily of primate-specific zinc finger genes.Genome research · 2006Article
- Krüppel-associated boxes are potent transcriptional repression domains.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Chromosomal localization of 9 KOX zinc finger genes: physical linkages suggest clustering of KOX genes on chromosomes 12, 16, and 19.Human genetics · 1993Article
- Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells.The EMBO journal · 1993Article
- New nucleotide sequence data on the EMBL File Server.Nucleic acids research · 1992Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A cDNA was isolated from a T cell library using an oligonucleotide probe corresponding to a sequence conserved in proteins with multiple zinc fingers of the C2H2 type. The predicted protein structure of this cDNA (ZNF43) showed that it contained 22 of the Krüppel type of zinc finger motifs in tandem. The amino acid sequence was strongly conserved between each of the finger domains of this cDNA, except for variable residue positions within the putative DNA binding site. Within the zinc finger domain the amino acid sequence of the four zinc fingers 6 to 9 was very similar to the amino acid sequence of fingers 10 to 13, the DNA sequence bound by this group of eight fingers may include a short repeat. Southern blotting showed that ZNF43 was one of a closely related family of proteins with 10 to 20 members. The members of the ZNF43 family did not appear to be clustered at the chromosomal level. The transcription of many members of this gene family was increased in lymphoid cell lines. After in vitro induced terminal differentiation of the human HL60 cell line the expression of the ZNF43 family was reduced. The expression of the ZNF43 gene was mainly limited to T and B cell lines. The gene was differentially spliced and different cell lines expressed different combinations of transcripts.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.