ArticlePediatrics2006
Impact of prenatal chlorpyrifos exposure on neurodevelopment in the first 3 years of life among inner-city children.
Article in Pediatrics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 310 papers, 10 of them syntheses that pooled it.
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Who cites it
310 citing papers in PubMed, 10 syntheses or guidelines pooled it.
- Investigating the role of food pollutants in autism spectrum disorder: a comprehensive analysis of heavy metals, pesticides, and mycotoxins.Naunyn-Schmiedeberg's archives of pharmacology · 2025Pooled it
- A Systematic Review and Meta-analysis of Chemical Exposures and Attention-Deficit/Hyperactivity Disorder in Children.Prevention science : the official journal of the Society for Prevention Research · 2024Pooled it
- Maternal exposure to pesticides and autism or attention-deficit/hyperactivity disorders in offspring: A meta-analysis.Chemosphere · 2023Pooled it
- A Meta-Analysis of Stressors from the Total Environment Associated with Children's General Cognitive Ability.International journal of environmental research and public health · 2020Pooled it
- Perinatal Exposure to Environmental Endocrine Disruptors in the Emergence of Neurodevelopmental Psychiatric Diseases: A Systematic Review.International journal of environmental research and public health · 2019Pooled it
- Developmental PBDE Exposure and IQ/ADHD in Childhood: A Systematic Review and Meta-analysis.Environmental health perspectives · 2017Pooled it
- Environmental risk factors for autism spectrum disorders.Der Nervenarzt · 2016Pooled it
- Contributions of a Child's Built, Natural, and Social Environments to Their General Cognitive Ability: A Systematic Scoping Review.PloS one · 2016Pooled it
- Environmental toxicants and autism spectrum disorders: a systematic review.Translational psychiatry · 2014Pooled it
- Neurodevelopmental effects in children associated with exposure to organophosphate pesticides: a systematic review.Neurotoxicology · 2013Pooled it
- Cognitive function following diabetic ketoacidosis in young children with type 1 diabetes.Endocrinology, diabetes & metabolism · 2023Trial
- Sustainable Waste-Derived Mineral-Carbon Composites as Reusable Sorbents for Solid-Phase Extraction of Selected Organophosphorus Pesticides from Water.Molecules (Basel, Switzerland) · 2026Article
- Embryotoxicity of pyrethroid insecticides and their mixtures in a human induced pluripotent stem cell-based model in vitro.Archives of toxicology · 2026Article
- Toxicological profiling and health hazard characterization of pesticides widely used in Tanzania unmarked.Toxicology reports · 2026Article
- Chlorpyrifos and Chlorpyrifos-Oxon: A Widening Spectrum of Toxicity.International journal of molecular sciences · 2026Review
- Suppression of haptoglobin and loss of striatal neurons in mice chronically exposed to chlorpyrifos-contaminated drinking water.Toxicological sciences : an official journal of the Society of Toxicology · 2026Article
- Sex andToxics · 2026Article
- From Genetic Determinism to Epigenetic Regulation: Paradigm Shifts in the Understanding of Neurodevelopmental Disorders.Current issues in molecular biology · 2026Review
- FIGO committee opinion: Environmental drivers of obstetric health and early childhood development.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025Article
- Associations between concurrent neonicotinoid, pyrethroid, and organophosphate insecticide metabolites and neurocognitive performance in Ecuadorian adolescents.The Science of the total environment · 2025Article
250 more citing papers are in PubMed but not listed here.
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9 authors.
Funding
Abstract
objectiveThe purpose of this study was to investigate the impact of prenatal exposure to chlorpyrifos on 3-year neurodevelopment and behavior in a sample of inner-city minority children.
methodsAs part of an ongoing prospective cohort study in an inner-city minority population, neurotoxicant effects of prenatal exposure to chlorpyrifos were evaluated in 254 children through the first 3 years of life. This report examined cognitive and motor development at 12, 24, and 36 months (measured with the Bayley Scales of Infant Development II) and child behavior at 36 months (measured with the Child Behavior Checklist) as a function of chlorpyrifos levels in umbilical cord plasma.
resultsHighly exposed children (chlorpyrifos levels of >6.17 pg/g plasma) scored, on average, 6.5 points lower on the Bayley Psychomotor Development Index and 3.3 points lower on the Bayley Mental Development Index at 3 years of age compared with those with lower levels of exposure. Children exposed to higher, compared with lower, chlorpyrifos levels were also significantly more likely to experience Psychomotor Development Index and Mental Development Index delays, attention problems, attention-deficit/hyperactivity disorder problems, and pervasive developmental disorder problems at 3 years of age.
conclusionsThe adjusted mean 36-month Psychomotor Development Index and Mental Development Index scores of the highly and lower exposed groups differed by only 7.1 and 3.0 points, respectively, but the proportion of delayed children in the high-exposure group, compared with the low-exposure group, was 5 times greater for the Psychomotor Development Index and 2.4 times greater for the Mental Development Index, increasing the number of children possibly needing early intervention services.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.