Trial reportAntimicrobial agents and chemotherapy2007
Estimating true antimalarial efficacy by heteroduplex tracking assay in patients with complex Plasmodium falciparum infections.
Trial report in Antimicrobial agents and chemotherapy, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 36 citations in OpenAlex.
- Residual Plasmodium falciparum parasitemia in Kenyan children after artemisinin-combination therapy is associated with increased transmission to mosquitoes and parasite recurrence.The Journal of infectious diseases · 2013Trial
- Persistence of Plasmodium falciparum parasites in infected pregnant Mozambican women after delivery.Infection and immunity · 2011Trial
- Antibodies to variant surface antigens of Plasmodium falciparum-infected erythrocytes are associated with protection from treatment failure and the development of anemia in pregnancy.The Journal of infectious diseases · 2009Trial
- Trial
- Assessing fitness costs in malaria parasites: a comprehensive review and implications for drug resistance management.Malaria journal · 2025Review
- The temporal dynamics of Plasmodium species infection after artemisinin-based combination therapy (ACT) among asymptomatic children in the Hohoe municipality, Ghana.Malaria journal · 2023Article
- Classification of disease recurrence using transition likelihoods with expectation-maximization algorithm.Statistics in medicine · 2022Article
- Genetic surveillance for monitoring the impact of drug use on Plasmodium falciparum populations.International journal for parasitology. Drugs and drug resistance · 2021Review
- Relapse or reinfection: Classification of malaria infection using transition likelihoods.Biometrics · 2020Article
- Using Amplicon Deep Sequencing to Detect Genetic Signatures of Plasmodium vivax Relapse.The Journal of infectious diseases · 2015Article
- Relevance of undetectably rare resistant malaria parasites in treatment failure: experimental evidence from Plasmodium chabaudi.The American journal of tropical medicine and hygiene · 2015Article
- Article
- Plasmodium vivax isolates from Cambodia and Thailand show high genetic complexity and distinct patterns of P. vivax multidrug resistance gene 1 (pvmdr1) polymorphisms.The American journal of tropical medicine and hygiene · 2013Article
- Individual Plasmodium vivax msp1 variants within polyclonal P. vivax infections display different propensities for relapse.Journal of clinical microbiology · 2012Article
- Estimating the numbers of malaria infections in blood samples using high-resolution genotyping data.PloS one · 2012Article
- Uncertain outcomes: adjusting for misclassification in antimalarial efficacy studies.Epidemiology and infection · 2011Article
- Exposing malaria in-host diversity and estimating population diversity by capture-recapture using massively parallel pyrosequencing.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- The perils of PCR: can we accurately 'correct' antimalarial trials?Trends in parasitology · 2010Article
- Gel versus capillary electrophoresis genotyping for categorizing treatment outcomes in two anti-malarial trials in Uganda.Malaria journal · 2010Article
- Misclassification of drug failure in Plasmodium falciparum clinical trials in southeast Asia.The Journal of infectious diseases · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Heteroduplex tracking assays (HTAs) of Plasmodium falciparum merozoite surface protein 1 block-2 were used to assess complexity of infection and treatment efficacy in a trial of three antimalarial treatments in 141 Malawian pregnant women. An elevated complexity of infection (COI) was associated with anemia, parasite burden, and human immunodeficiency virus infection but was not associated with age or gravidity. Comparisons of HTA patterns before and after treatment allowed the classification of 20 of 30 (66%) recurrent episodes as either definite treatment failures or reinfections. An elevated COI was strongly associated with treatment failure (P=0.003). An algorithm was developed to assign a probability of failure for the 10 indeterminate participants, some of whose infections shared a single variant of high prevalence (>10%). By summing these probabilities, treatment efficacy was estimated.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.