ArticleAntimicrobial agents and chemotherapy2007
Fitness costs of fluoroquinolone resistance in Streptococcus pneumoniae.
Article in Antimicrobial agents and chemotherapy, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.
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Who cites it
77 citing papers in PubMed.
- Pathogen characteristics are key determinants of distinct host response phenotypes of sepsis.The Journal of clinical investigation · 2026Observational
- Fitness costs of phage-driven resistance mutations inJournal of virology · 2026Article
- Fluoroquinolone resistance in ESKAPE pathogens: evolutionary pathways, one health transmission, and clinical surveillance.Frontiers in microbiology · 2025Review
- Costs of antibiotic resistance genes depend on host strain and environment and can influence community composition.Proceedings. Biological sciences · 2024Article
- Article
- Horizontal gene transfer facilitates the molecular reverse-evolution of antibiotic sensitivity in experimental populations of H. pylori.Nature ecology & evolution · 2024Article
- Chance Favors the Prepared Genomes: Horizontal Transfer Shapes the Emergence of Antibiotic Resistance Mutations in Core Genes.Molecular biology and evolution · 2023Article
- Allele-specific collateral and fitness effects determine the dynamics of fluoroquinolone resistance evolution.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- The cost of evolved constitutiveEcology and evolution · 2021Article
- Historical contingency in the evolution of antibiotic resistance after decades of relaxed selection.PLoS biology · 2019Article
- Microbial Experimental Evolution - a proving ground for evolutionary theory and a tool for discovery.EMBO reports · 2019Review
- Resistance diagnostics as a public health tool to combat antibiotic resistance: A model-based evaluation.PLoS biology · 2019Article
- Genome-wide discovery of epistatic loci affecting antibiotic resistance in Neisseria gonorrhoeae using evolutionary couplings.Nature microbiology · 2019Article
- Article
- Vaccination can drive an increase in frequencies of antibiotic resistance among nonvaccine serotypes ofProceedings of the National Academy of Sciences of the United States of America · 2018Article
- A comparison study of the potential risks induced in arable land and forest soils by carcass-derived pollutants.Environmental geochemistry and health · 2018Article
- Prediction of antibiotic resistance: time for a new preclinical paradigm?Nature reviews. Microbiology · 2017Review
- Cryptic Microheteroresistance Explains Mycobacterium tuberculosis Phenotypic Resistance.American journal of respiratory and critical care medicine · 2017Article
- Environmental and genetic modulation of the phenotypic expression of antibiotic resistance.FEMS microbiology reviews · 2017Review
- Article
17 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors.
Funding
Abstract
The fitness cost of the genes responsible for resistance to fluoroquinolones in clinical isolates of Streptococcus pneumoniae were estimated in vitro in a common genetic background. Naturally occurring parC, parE, and gyrA loci containing mutations in the quinolone-resistance-determining regions were introduced by transformation into S. pneumoniae strain R6 individually and in combinations. The fitness of these transformants was estimated by pairwise competition experiments with a common R6 strain. On average, single par and gyr mutants responsible for low-level MIC resistance (first-step resistance) impose a fitness burden of approximately 8%. Some of these mutants engender no measurable cost, while one, a parE mutant, reduces the fitness of these bacteria by more than 40%. Most interestingly, the addition of the second par or gyr mutations required for clinically significant, high-MIC fluoroquinolone resistance does not increase the fitness burden imposed by these single genes and can even reduce it. We discuss the implications of these results for the epidemiology of fluoroquinolone resistance and the evolution of acquired resistance in treated patients.
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