ReviewJournal of mammary gland biology and neoplasia2006
Illuminating the center: mechanisms regulating lumen formation and maintenance in mammary morphogenesis.
Review in Journal of mammary gland biology and neoplasia, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- Characterization of Organoid Cultures to Study the Effects of Pregnancy Hormones on the Epigenome and Transcriptional Output of Mammary Epithelial Cells.Journal of mammary gland biology and neoplasia · 2020Review
- Harnessing 3D models of mammary epithelial morphogenesis: An off the beaten path approach to identify candidate biomarkers of early stage breast cancer.Cancer letters · 2016Article
- Aberrant activation of NF-κB signaling in mammary epithelium leads to abnormal growth and ductal carcinoma in situ.BMC cancer · 2015Article
- Scribble modulates the MAPK/Fra1 pathway to disrupt luminal and ductal integrity and suppress tumour formation in the mammary gland.PLoS genetics · 2014Article
- The oncogene HER2/neu (ERBB2) requires the hypoxia-inducible factor HIF-1 for mammary tumor growth and anoikis resistance.The Journal of biological chemistry · 2013Article
- The 18-kDa translocator protein (TSPO) disrupts mammary epithelial morphogenesis and promotes breast cancer cell migration.PloS one · 2013Article
- Article
- CPEB-mediated ZO-1 mRNA localization is required for epithelial tight-junction assembly and cell polarity.Nature communications · 2012Article
- p130Cas over-expression impairs mammary branching morphogenesis in response to estrogen and EGF.PloS one · 2012Article
- Article
- A novel MCF-10A line allowing conditional oncogene expression in 3D culture.Cell communication and signaling : CCS · 2011Article
- Phenotypic transition maps of 3D breast acini obtained by imaging-guided agent-based modeling.Integrative biology : quantitative biosciences from nano to macro · 2011Article
- Hypoxia suppression of Bim and Bmf blocks anoikis and luminal clearing during mammary morphogenesis.Molecular biology of the cell · 2010Article
- Linking changes in epithelial morphogenesis to cancer mutations using computational modeling.PLoS computational biology · 2010Article
- Cell polarity in motion: redefining mammary tissue organization through EMT and cell polarity transitions.Journal of mammary gland biology and neoplasia · 2010Review
- ErbB2 requires integrin alpha5 for anoikis resistance via Src regulation of receptor activity in human mammary epithelial cells.Journal of cell science · 2010Article
- ErbB3 is required for ductal morphogenesis in the mouse mammary gland.Breast cancer research : BCR · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The lumens present in ductal structures are required for transport of fluids and air. Studies in model organisms and cells in culture suggest that lumens can be generated by multiple mechanisms including apoptosis of centrally located cells, and re-modeling of epithelia. Several studies point to a role for apoptosis during lumen formation in the mammary ducts. However, a role for other mechanisms during lumen formation in the mammary ducts is largely unexplored. Understanding how lumens are formed and maintained free of cells is of clinical importance because filling of the luminal space is associated with cancer and inflammation. Thus, further investigation can lead to new diagnostic and therapeutic opportunities.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.