ArticleEuropean journal of applied physiology2007
Causes of differences in exercise-induced changes of base excess and blood lactate.
Article in European journal of applied physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 38 citations in OpenAlex.
- Biochemical responses and physical performance during high-intensity resistance circuit training in hypoxia and normoxia.European journal of applied physiology · 2017Trial
- Effects of bicarbonate ingestion and high intensity exercise on lactate and H(+)-ion distribution in different blood compartments.European journal of applied physiology · 2011Trial
- Quantifying pH-induced changes in plasma strong ion difference during experimental acidosis: clinical implications for base excess interpretation.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- The oxygen dissociation curve of blood in COVID-19-An update.Frontiers in medicine · 2023Review
- Orosomucoid: a promising biomarker for the assessment of exercise-induced fatigue triggered by basic combat training.BMC sports science, medicine & rehabilitation · 2022Article
- Comprehensive evaluation of military training-induced fatigue among soldiers in China: A Delphi consensus study.Frontiers in public health · 2022Article
- The oxygen dissociation curve of blood in COVID-19.American journal of physiology. Lung cellular and molecular physiology · 2021Review
- Relation between lactic acid and base excess during muscular exercise.European journal of applied physiology · 2018Article
- Effect of self-paced active recovery and passive recovery on blood lactate removal following a 200 m freestyle swimming trial.Open access journal of sports medicine · 2017Article
- Hemoglobin oxygen affinity in patients with cystic fibrosis.PloS one · 2014Article
- A mathematical model for lactate transport to red blood cells.The journal of physiological sciences : JPS · 2011Article
- Warming-Up Affects Performance and Lactate Distribution between Plasma and Red Blood Cells.Journal of sports science & medicine · 2010Article
- Extracellular pH defense against lactic acid in untrained and trained altitude residents.European journal of applied physiology · 2008Article
- Extracellular bicarbonate and non-bicarbonate buffering against lactic acid during and after exercise.European journal of applied physiology · 2007Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been concluded from comparisons of base excess (BE) and lactic acid (La) concentration changes in blood during exercise-induced acidosis that more H+ than La- leave the muscle and enter interstitial fluid and blood. To examine this, we performed incremental cycle tests in 13 untrained males and measured acid-base status and [La] in arterialized blood, plasma, and red cells until 21 min after exhaustion. The decrease of actual BE (-deltaABE) was 2.2 +/- 0.5 (SEM) mmol l(-1) larger than the increase of [La]blood at exhaustion, and the difference rose to 4.8 +/- 0.5 mmol l(-1) during the first minutes of recovery. The decrease of standard BE (SBE), a measure of mean BE of interstitial fluid (if) and blood, however, was smaller than the increase of [La] in the corresponding volume (delta[La](if+blood)) during exercise and only slightly larger during recovery. The discrepancy between -deltaABE and delta[La]blood mainly results from the Donnan effect hindering the rise of [La]erythrocyte to equal values like [La]plasma. The changing Donnan effect during acidosis causes that Cl- from the interstitial fluid enter plasma and erythrocytes in exchange for HCO3(-). A corresponding amount of La- remains outside the blood. SBE is not influenced by ion shifts among these compartments and therefore is a rather exact measure of acid movements across tissue cell membranes, but changes have been compared previously to delta[La]blood instead to delta[La](if+blood). When performing correct comparisons and considering Cl-/HCO3(-) exchange between erythrocytes and extracellular fluid, neither the use of deltaABE nor of deltaSBE provides evidence for differences in H+ and La- transport across the tissue cell membranes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.