Trial reportJournal of endocrinological investigation2006
GH response to hypoglycemia and clonidine in the GH-releasing hormone resistance syndrome.
Trial report in Journal of endocrinological investigation, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- Brain morphometry and estimation of aging brain in subjects with congenital untreated isolated GH deficiency.Journal of endocrinological investigation · 2024Article
- The state of Sergipe contribution to GH research: from Souza Leite to Itabaianinha syndrome.Archives of endocrinology and metabolism · 2022Review
- Disruption of the GHRH receptor and its impact on children and adults: The Itabaianinha syndrome.Reviews in endocrine & metabolic disorders · 2021Review
- Circulating aryl hydrocarbon receptor-interacting protein (AIP) is independent of GH secretion.Endocrine connections · 2019Article
- Growth Hormone Deficiency: Health and Longevity.Endocrine reviews · 2019Review
- Macrophages From Subjects With Isolated GH/IGF-I Deficiency Due to a GHRH Receptor Gene Mutation Are Less Prone to Infection byFrontiers in cellular and infection microbiology · 2019Article
- Infectious diseases and immunological responses in adult subjects with lifetime untreated, congenital GH deficiency.Endocrine · 2016Article
- Subjects with isolated GH deficiency due to a null GHRHR mutation eat proportionally more, but healthier than controls.Endocrine · 2016Article
- Lifetime congenital isolated GH deficiency does not protect from the development of diabetes.Endocrine connections · 2013Article
- Cephalometric features in isolated growth hormone deficiency.The Angle orthodontist · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
Abstract
GH secretion by the pituitary is the result of the balance between the stimulatory effect of GHRH and the inhibitory effect of SS. Patients with mutations in GHRH receptor (GHRH-R) gene (GHRH-R) offer a unique model to study the mechanism of action of different GH secretion stimuli. In the past, we have demonstrated a small but significant GH response to a GH secretagogue (GHRP-2) in a homogenous cohort of patients with severe GH deficiency (GHD) due to a homozygous null mutation in GHRH-R (IVS1+1G-->A). Now, we sought to determine if we could detect a GH response to hypoglycemia (ITT: insulin tolerance test) or clonidine (CL) in these patients. Nine young GHD subjects underwent both ITT and CL tests, and 2 additional subjects underwent only CL test. There was a small but significant GH increase during ITT, but not during CL test. These results indicate that a minimal albeit significant GH response to ITT can occur despite complete lack of GHRH-R function.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.