Cortisol, dehydroepiandrosterone sulphate and dehydroepiandrosterone sulphate/cortisol ratio responses to physical stress in males are influenced by pubertal development.

L Di Luigi, L Guidetti, C Baldari, M C Gallotta, P Sgrò, F Perroni, F Romanelli, A Lenzi

Abstract read

In one paragraph

Article in Journal of endocrinological investigation, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it

0cells of the map it votes in

9citing papers in PubMed

0.6field-weighted citation impact, top 44% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 38 citations in OpenAlex.

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Trial
Endogenous glucocorticoids and human immunity: Time to revisit old dogmas.Seminars in immunology · 2025
Review
The implications of socioeconomic factors on salivary bioscience methodological variables in a large pediatric multi-site study.Frontiers in public health · 2023
Article
Effects of physical activity in child and adolescent depression and anxiety: role of inflammatory cytokines and stress-related peptide hormones.Frontiers in neuroscience · 2023
Review
The impact of an exercise training intervention on cortisol levels and post-traumatic stress disorder in juveniles from an Ugandan refugee settlement: study protocol for a randomized control trial.Trials · 2018
Article
Depressed suicidal adolescent males have an altered cortisol response to a pharmacological challenge.Asian journal of psychiatry · 2014
Article
Framework for sex differences in adolescent neurobiology: a focus on cannabinoids.Neuroscience and biobehavioral reviews · 2011
Review
Measuring DHEA-S in saliva: time of day differences and positive correlations between two different types of collection methods.BMC research notes · 2010
Article
Influence of intense exercise on saliva glutathione in prepubescent and pubescent boys.European journal of applied physiology · 2009
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

L Di LuigiUnit of Endocrinology, Department of Health Sciences, University of Rome IUSM, Rome, Italy. iusm.endocrinol@iusm.it

L Guidetti

C Baldari

M C Gallotta

P Sgrò

F Perroni

F Romanelli

A Lenzi

Sapienza University of Rome · ITForo Italico University of Rome · ITSaint Camillus International University of Health and Medical Sciences · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To evaluate the influence of chronological age and pubertal development on the hypothalamus-pituitary-adrenal (HPA) axis response to stress, we studied the possible correlations between male pubertal characteristics and salivary cortisol (C), DHEAS and the DHEAS/C ratio before (pre-stress) and after acute exercise-stress in young male volunteers (no. 87; 13.3+/-2.1 yr). In our overall study population, the mean pre-stress salivary C and DHEAS concentrations, significantly increased after exercise-related stress, whereas the DHEAS/C ratio significantly decreased. Pre-stress salivary C was positively correlated with chronological age, and after-stress salivary C concentration variations were negatively correlated with pubertal stage, mean testis volume and pre-stress salivary DHEAS. Furthermore, salivary DHEAS concentrations and the DHEAS/C ratio, before and after exercise stress, were positively correlated with chronological age, pubertal stage, pre-stress salivary testosterone (T), testis volume and body mass index (BMI). In contrast with late pubertal stages (P4, P5), young individuals at early stages of puberty (P1 to P3) showed higher C increase and lower DHEAS/C ratio after exercise-related stress. In conclusion, since C is also a mediator of stress-related negative effects on health and the DHEAS/C ratio has been hypothesized as an index for the degree to which an individual is buffered against the negative effects of stress, these data might suggest potentially increased stress-related risks at early stages of male puberty.

Indexed as

AdolescentChildDehydroepiandrosterone SulfateExerciseHuman DevelopmentHumansHydrocortisoneMalePubertyPuberty, DelayedPuberty, PrecociousSalivaStress, PhysiologicalDehydroepiandrosterone SulfateHydrocortisone

Identifiers

PMID17114910

DOI10.1007/BF03347373

OpenAlexW2035799822

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.