ArticleJournal of immunology (Baltimore, Md. : 1950)2006
The Duffy antigen modifies systemic and local tissue chemokine responses following lipopolysaccharide stimulation.
Article in Journal of immunology (Baltimore, Md. : 1950), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it, 84 citations in OpenAlex.
- Genome-wide association study of white blood cell count in 16,388 African Americans: the continental origins and genetic epidemiology network (COGENT).PLoS genetics · 2011Pooled it
- Analyses of genome wide association data, cytokines, and gene expression in African-Americans with benign ethnic neutropenia.PloS one · 2018Trial
- Trial
- Inflammatory response to percutaneous coronary intervention in stable coronary artery disease.Journal of thrombosis and thrombolysis · 2011Trial
- Association of the rs2814778 variant in the ACKR1 gene, responsible for the Duffy erythrocyte antigen "null" phenotype, with COVID-19 severity in Southern Brazil.Einstein (Sao Paulo, Brazil) · 2026Article
- Emerging concepts in the molecular cell biology and functions of mammalian erythrocytes.The Journal of biological chemistry · 2025Review
- Developing an erythrocyte‒MHC-I conjugate for cancer treatment.Cell discovery · 2024Article
- Increased Neutrophil HResearch square · 2024Article
- Red Blood Cell-Related Parameters in Rheumatoid Arthritis: Clinical Value and Immunological Significance.Journal of inflammation research · 2024Review
- The ultimate tradeoff: how red cell adaptations to malaria alter the host response during critical illness.American journal of physiology. Lung cellular and molecular physiology · 2023Review
- Review
- COVID-19: Mechanistic Model of the African Paradox Supports the Central Role of the NF-κB Pathway.Viruses · 2021Review
- Regulatory mechanisms of neutrophil migration from the circulation to the airspace.Cellular and molecular life sciences : CMLS · 2021Review
- The Red Blood Cell-Inflammation Vicious Circle in Sickle Cell Disease.Frontiers in immunology · 2020Review
- The Evolving Erythrocyte: Red Blood Cells as Modulators of Innate Immunity.Journal of immunology (Baltimore, Md. : 1950) · 2018Review
- The Duffy antigen receptor for chemokines regulates asthma pathophysiology.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2017Article
- CD36 Provides Host Protection Against Klebsiella pneumoniae Intrapulmonary Infection by Enhancing Lipopolysaccharide Responsiveness and Macrophage Phagocytosis.The Journal of infectious diseases · 2016Article
- Atypical Chemokine Receptors and Their Roles in the Resolution of the Inflammatory Response.Frontiers in immunology · 2016Review
- Shedding light on HSC dormancy-a role for the DARC.Stem cell investigation · 2016Article
- A pilot study to determine the normal haematological indices for young Malawian adults in Blantyre, Malawi.Malawi medical journal : the journal of Medical Association of Malawi · 2015Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 1 country.
Funding
Abstract
The Duffy blood group Ag (dfy) binds selective CXC and CC chemokines at high affinity and is expressed on erythrocytes and endothelial cells. However, it does not transmit a signal via G proteins, as occurs with other seven-transmembrane receptors. We hypothesized that dfy functions as a chemokine reservoir and regulates inflammation by altering soluble chemokine concentrations in the blood and tissue compartments. We determined whether Duffy Ag "loss-of-function" phenotypes (human and murine) are associated with alterations in plasma chemokine concentrations during the innate inflammatory response to LPS. Plasma CXCL8 and CCL2 concentrations from humans homozygous for the GATA-1 box polymorphism, a dfy polymorphism that abrogates erythrocyte chemokine binding, were higher than in heterozygotes following LPS stimulation of their whole blood in vitro. Similarly, dfy(-/-) mice showed higher plasma MIP-2 concentrations than dfy(+/+) mice following LPS stimulation of whole blood in vitro. We then determined the relative contributions of erythrocyte and endothelial Duffy Ag in modifying chemokine concentrations and neutrophil recruitment in the lungs following intratracheal LPS administration in dfy(-/-) and dfy(+/+) mice reconstituted with dfy(-/-) or dfy(+/+) marrow. Mice lacking endothelial dfy expression had higher MIP-2 and keratinocyte chemoattractant concentrations in the airspaces. Mice lacking erythrocyte dfy had higher MIP-2 and keratinocyte chemoattractant concentrations in the lung tissue vascular space, but lower plasma chemokine concentrations associated with attenuated neutrophil recruitment into the airspaces. These data indicate that dfy alters soluble chemokine concentrations in blood and local tissue compartments and enhances systemic bioavailability of chemokines produced during local tissue inflammation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.