ArticleProceedings of the National Academy of Sciences of the United States of America2006
Mst3b, a purine-sensitive Ste20-like protein kinase, regulates axon outgrowth.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 69 citations in OpenAlex.
- Efficacy and Safety of Fixed Dose Combination of Inosine Monophosphate, Agmatine Sulphate, and L-Carnosine (CGXNW) as Add-on Therapy for the Management of Spinal Cord Injury - A Randomized Controlled Clinical Trial.Journal of orthopaedic case reports · 2026Article
- 8-Aminoguanine protects against paclitaxel-induced neural degeneration and mechanical allodynia.JCI insight · 2026Article
- Combination of Treadmill Training and Inosine Enhance Nerve Regeneration and Functional Recovery After Mice Sciatic Nerve Transection.Journal of neuroscience research · 2025Article
- Stk24 deficiency causes disrupted hippocampal neurogenesis and anxiety-like behavior in mice.Communications biology · 2025Article
- An Untargeted Metabolomic Analysis ofMicroorganisms · 2024Article
- Purine nucleoside phosphorylase inhibition is an effective approach for the treatment of chemical hemorrhagic cystitis.JCI insight · 2024Article
- Molecular mechanisms involved in regulating protein activity and biological function of MST3.Cell division · 2023Review
- Inosine as a Tool to Understand and Treat Central Nervous System Disorders: A Neglected Actor?Frontiers in neuroscience · 2021Review
- Inosine: a novel treatment for sciatic nerve injury.Neural regeneration research · 2021Article
- STK24 modulates excitatory synaptic transmission in epileptic hippocampal neurons.CNS neuroscience & therapeutics · 2020Article
- Mammalian Sterile20-like Kinases: Signalings and Roles in Central Nervous System.Aging and disease · 2018Review
- Inosine - a Multifunctional Treatment for Complications of Neurologic Injury.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology · 2018Review
- Inosine attenuates spontaneous activity in the rat neurogenic bladder through an AScientific reports · 2017Article
- Inosine enhances recovery of grasp following cortical injury to the primary motor cortex of the rhesus monkey.Restorative neurology and neuroscience · 2016Article
- Molecular Pathways Underlying Projection Neuron Production and Migration during Cerebral Cortical Development.Frontiers in neuroscience · 2015Review
- Mst3b promotes spinal cord neuronal regeneration by promoting growth cone branching out in spinal cord injury rats.Molecular neurobiology · 2015Article
- MST3 kinase phosphorylates TAO1/2 to enable Myosin Va function in promoting spine synapse development.Neuron · 2014Article
- Cdk5-dependent Mst3 phosphorylation and activity regulate neuronal migration through RhoA inhibition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Axon-soma communication in neuronal injury.Nature reviews. Neuroscience · 2014Review
- The GCKIII kinase Sps1 and the 14-3-3 isoforms, Bmh1 and Bmh2, cooperate to ensure proper sporulation in Saccharomyces cerevisiae.PloS one · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The growth of axons is fundamental to the development and repair of brain circuitry. We show here that Mst3b, a neuron-specific homolog of the yeast kinase Ste20, is critical for axon outgrowth. Mst3b is activated in response to trophic factors, and suppressing its expression (via siRNAs) or its function (by a dominant-negative mutant) blocks axon outgrowth. Inosine, a purine nucleoside that stimulates axon outgrowth, activates Mst3b kinase activity, whereas 6-thioguanine, a purine analog that blocks outgrowth, inhibits the activity of this kinase. These findings place Mst3b as a key regulator of axon outgrowth and help explain the purine sensitivity of this process.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.