ArticleBiophysical journal2007
Bending elasticity of anti-parallel beta-sheets.
Article in Biophysical journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 11 citations in OpenAlex.
- A multiscale model of mechanotransduction by the ankyrin chains of the NOMPC channel.The Journal of general physiology · 2019Article
- Physics of bacterial morphogenesis.Microbiology and molecular biology reviews : MMBR · 2011Review
- The elastic properties of the structurally characterized myosin II S2 subdomain: a molecular dynamics and normal mode analysis.Biophysical journal · 2008Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Using a coarse-grained elastic model, we examine the bending properties of anti-parallel beta-sheets comprised of uniform amino-acid residues in vacuum as well as in explicit solvent. By comparing the conformational probability of the beta-sheet from molecular dynamics simulations with the same quantities obtained from the coarse-grained model, we compute the elastic bending constant, kappa. Equilibrium fluctuations of the beta-sheet and its response to external forces are well reproduced by a model with a uniform isotropic bending constant. An anisotropic bending model is also investigated, although the computed anisotropy is relatively weak and most of the observed properties are well described by an isotropic model. The presence of explicit solvent also lowers the bending constant. The sequence dependence of our result and its implications in protein conformational dynamics are discussed.
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