ArticleBiophysical journal2007
Membrane simulations of OpcA: gating in the loops?
Article in Biophysical journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Gating of β-Barrel Protein Pores, Porins, and Channels: An Old Problem with New Facets.International journal of molecular sciences · 2023Review
- What have molecular simulations contributed to understanding of Gram-negative bacterial cell envelopes?Microbiology (Reading, England) · 2022Review
- Tight Turns of Outer Membrane Proteins: An Analysis of Sequence, Structure, and Hydrogen Bonding.Journal of molecular biology · 2018Article
- Membrane Protein Structure, Function, and Dynamics: a Perspective from Experiments and Theory.The Journal of membrane biology · 2015Review
- Does the lipid environment impact the open-state conductance of an engineered β-barrel protein nanopore?Biochimica et biophysica acta · 2013Article
- Modeling and simulation of ion channels.Chemical reviews · 2012Review
- Inspection of the engineered FhuA ΔC/Δ4L protein nanopore by polymer exclusion.Biophysical journal · 2012Article
- Cation selectivity is a conserved feature in the OccD subfamily of Pseudomonas aeruginosa.Biochimica et biophysica acta · 2012Article
- Article
- OccK channels from Pseudomonas aeruginosa exhibit diverse single-channel electrical signatures but conserved anion selectivity.Biochemistry · 2012Article
- Analysis of gating transitions among the three major open states of the OpdK channel.Biochemistry · 2011Article
- Neisseria meningitidis Opc invasin binds to the sulphated tyrosines of activated vitronectin to attach to and invade human brain endothelial cells.PLoS pathogens · 2010Article
- Article
- Coupling of calcium and substrate binding through loop alignment in the outer-membrane transporter BtuB.Journal of molecular biology · 2009Article
- Neisseria meningitidis Opc invasin binds to the cytoskeletal protein alpha-actinin.Cellular microbiology · 2009Article
- Gating at both ends and breathing in the middle: conformational dynamics of TolC.Biophysical journal · 2008Article
- Coarse-grained simulations of the membrane-active antimicrobial Peptide maculatin 1.1.Biophysical journal · 2008Article
- The TpsB translocator HMW1B of haemophilus influenzae forms a large conductance channel.The Journal of biological chemistry · 2008Article
- Structure refinement of the OpcA adhesin using molecular dynamics.Biophysical journal · 2007Article
- Functional fragments of disorder in outer membrane β barrel proteins.Intrinsically disordered proteinsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Mobility of extracellular loops may play an important role in the function of outer membrane proteins from Gram-negative bacteria. Molecular dynamics simulations of OpcA from Neisseria meningitidis, embedded in a lipid bilayer, have been used to explore the relationship between the crystal structure and dynamic function of this protein. The results suggest that the crystal environment may constrain the membrane protein structure in a nonphysiological state. The presence of lipids and physiological salt concentrations result in changes in the conformation of the extracellular loops of OpcA, leading to opening of a pore, and to modulation of the molecular surface implicated in recognition of proteoglycan. These changes may be related to the role of OpcA in pathogenesis via modulation of the conformation of a possible sialic acid binding site.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.