ArticleBiophysical journal2007
Hydration changes accompanying the binding of minor groove ligands with DNA.
Article in Biophysical journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Syntheses, DNA interactions, and photodynamic antimicrobial properties of near-infrared indolium carbocyanine dyes.RSC advances · 2026Article
- Coumarin 6H-fused fluorescent probe for highly sensitive detection of coralyne using oligonucleotide-modified silver nanoparticles.Analytical and bioanalytical chemistry · 2022Article
- Bound Compound, Interfacial Water, and Phenyl Ring Rotation Dynamics of a Compound in the DNA Minor Groove.Biochemistry · 2018Article
- Investigation of the electrostatic and hydration properties of DNA minor groove-binding by a heterocyclic diamidine by osmotic pressure.Biophysical chemistry · 2017Article
- Binding of Cu(II) complexes of oxicam NSAIDs to alternating AT and homopolymeric AT sequences: differential response to variation in backbone structure.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2012Article
- Structure and stability of higher-order human telomeric quadruplexes.Journal of the American Chemical Society · 2011Article
- Complexity in the binding of minor groove agents: netropsin has two thermodynamically different DNA binding modes at a single site.Nucleic acids research · 2011Article
- Hydration of drug-DNA complexes: greater water uptake for adriamycin compared to daunomycin.Journal of medicinal chemistry · 2008Article
- Dissociation of minor groove binders from DNA: insights from metadynamics simulations.Nucleic acids research · 2008Article
- Influence of DNA structure on adjacent site cooperative binding.The journal of physical chemistry. B · 2008Article
- Antiparasitic compounds that target DNA.Biochimie · 2008Review
- Inhibition of high-mobility-group A2 protein binding to DNA by netropsin: a biosensor-surface plasmon resonance assay.Analytical biochemistry · 2008Article
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Authors and funding
5 authors.
Funding
Abstract
4',6-diamidino-2-phenylindole (DAPI), netropsin, and pentamidine are minor groove binders that have terminal -C(NH2)2+ groups. The hydration changes that accompany their binding to the minor groove of the (AATT)2 sequence have been studied using the osmotic stress technique with fluorescence spectroscopy. The affinity of DAPI for the binding site decreases with the increasing osmolality of the solution, resulting in acquisition of 35+/-1 waters upon binding. A competition fluorescence assay was utilized to measure the binding constants and hydration changes of the other two ligands, using the DNA-DAPI complex as the fluorescence reporter. Upon their association to the (AATT)2 binding site, netropsin and pentamidine acquire 26+/-3 and 34+/-2 additional waters of hydration, respectively. The hydration changes are discussed in the context of the terminal functional groups of the ligands and conformational changes in the DNA.
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