ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2006
Pancreatic regeneration in chronic pancreatitis requires activation of the notch signaling pathway.
Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Uncertain Beginnings: Acinar and Ductal Cell Plasticity in the Development of Pancreatic Cancer.Cellular and molecular gastroenterology and hepatology · 2022Review
- Pancreatic islet regeneration through PDX-1/Notch-1/Ngn3 signaling after gastric bypass surgery in db/db mice.Experimental and therapeutic medicine · 2017Article
- Notch-Mediated Cell Adhesion.Biology · 2016Review
- Notch Signaling in Pancreatic Development.International journal of molecular sciences · 2015Review
- Aspartate β-Hydroxylase expression promotes a malignant pancreatic cellular phenotype.Oncotarget · 2015Article
- Zebrafish reporter lines reveal in vivo signaling pathway activities involved in pancreatic cancer.Disease models & mechanisms · 2014Article
- An evolutionary-conserved function of mammalian notch family members as cell adhesion molecules.PloS one · 2014Article
- Genes involved in type 1 diabetes: an update.Genes · 2013Article
- Relaxin prevents cardiac fibroblast-myofibroblast transition via notch-1-mediated inhibition of TGF-β/Smad3 signaling.PloS one · 2013Article
- Innate immune signaling in the pathogenesis of necrotizing enterocolitis.Clinical & developmental immunology · 2013Review
- Intestinal epithelial Toll-like receptor 4 regulates goblet cell development and is required for necrotizing enterocolitis in mice.Gastroenterology · 2012Article
- Aberrant signaling pathways in pancreatic cancer: a two compartment view.Molecular carcinogenesis · 2012Article
- Ligand-dependent Notch signaling is involved in tumor initiation and tumor maintenance in pancreatic cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2009Article
- Notch activates cell cycle reentry and progression in quiescent cardiomyocytes.The Journal of cell biology · 2008Article
- Notch signaling regulates regeneration in the avian retina.Developmental biology · 2007Article
- Candidate circulating microRNA biomarkers in dogs with chronic pancreatitis.Journal of veterinary internal medicineArticle
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic pancreatitis as an inflammatory process characterized by morphological changes, pancreatic dysfunction, and pain. During pancreatic injury and repair the Notch signaling pathway is reinstated. The current study analyzed this pathway in chronic pancreatitis and characterized its influence on fibrogenesis. Real-time quantitative PCR and immunohistochemistry were used for expression studies. Notch activation was determined by a specific luciferase-HES-1-reporter gene constructs. Cells were stimulated with alcohol, glucose, bile acids, and steroids. Notch-2, -3, and -4 mRNA, were overexpressed in chronic pancreatitis specimens. The ligands Jagged-1, -2, and Delta-1 were highly overexpressed. Jagged-1 and Notch receptors were observed in nerves, regenerating exocrine cells, and endocrine cells. Delta staining was present in ductal but not in acinus cells and not in nerves. Activation of Notch signaling was detectable upon cell stimulation with glucose, steroids, and bile acids. High glucose levels were further associated with increased collagen-I production. The Notch pathway is reactivated during chronic pancreatitis. Among the stimuli activating the Notch pathway are steroids, high glucose levels, and bile acids. These findings suggest a possible role of the Notch pathway during pancreatic regeneration since Jagged-1 inhibits inducible collagen-1 production, suggesting a new mechanism of tissue repair in this disease.
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