Evidence map›Paper›PMID 17113310›Full record

ArticleNeuroImage2007

Metabolic brain networks associated with cognitive function in Parkinson's disease.

Chaorui Huang, Paul Mattis, Chengke Tang, Kenneth Perrine, Maren Carbon, David Eidelberg

Open access · greenAbstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 179 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
179citing papers in PubMed, 6 pooled it
9.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

179 citing papers in PubMed, 6 syntheses or guidelines pooled it, 354 citations in OpenAlex.

  1. Pooled it
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  6. Pooled it
  7. Trial
  8. Abnormal metabolic pattern associated with cognitive impairment in Parkinson's disease: a validation study.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2015
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  11. Article
  12. Review
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  16. Article
  17. Dietary tributyrin supplementation in Parkinson's disease: An open-label target engagement study.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Article
  18. Article
  19. Article
  20. Article

119 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Chaorui HuangCenter for Neurosciences, The Feinstein Institute for Medical Research, North Shore-Long Island Jewish Health System, Department of Neurology and Medicine, North Shore University Hospital and New York University School of Medicine, New York, NY 11030, USA.
Paul Mattis
Chengke Tang
Kenneth Perrine
Maren Carbon
David Eidelberg
Feinstein Institute for Medical Research · USNorthwell Health · USCenter for Neurosciences · USNorth Shore University Hospital · US

Funding

WHITE MATTER STRUCTURAL DEFICITS IN HIGH FUNCTIONING CHILDREN WITH AUTISM SPEM01RR018535 · NCRR · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI SCHWARTZ, GUY · 2003 to 2010
$19.5M
PET IN PARKINSONISM: A MULTICENTER COLLABORATIVE STUDYR01NS035069 · NINDS · NORTH SHORE UNIVERSITY HOSPITAL · PI EIDELBERG, DAVID · 1996 to 2003
$3.4M
NCRR NIH HHS M01 RR018535NCRR NIH HHS RR M01 018535NINDS NIH HHS R01 NS035069PHS HHS R01 35069
6 · The paper itself

Abstract

The motor manifestations of Parkinson's disease (PD) have been linked to an abnormal spatial covariance pattern involving basal ganglia thalamocortical pathways. By contrast, little is known about the functional networks that underlie cognitive dysfunction in this disorder. To identify such patterns, we studied 15 non-demented PD patients using FDG PET and a voxel-based network modeling approach. We detected a significant covariance pattern that correlated (p<0.01) with performance on tests of memory and executive functioning. This PD-related cognitive pattern (PDCP) was characterized by metabolic reductions in frontal and parietal association areas and relative increases in the cerebellar vermis and dentate nuclei. To validate this pattern, we analyzed data from 32 subsequent PD patients of similar age, disease duration and severity. Prospective measurements of PDCP activity predicted memory performance (p<0.005), visuospatial function (p<0.01), and perceptual motor speed (p<0.005) in this validation sample. PDCP scores additionally exhibited an excellent degree of test-retest reliability (intraclass correlation coefficient, ICC=0.89) in patients undergoing repeat FDG PET at an 8-week interval. Unlike the PD-related motor pattern, PDCP expression was not significantly altered by antiparkinsonian treatment with either intravenous levodopa or deep brain stimulation (DBS). These findings substantiate the PDCP as a reproducible imaging marker of cognitive function in PD. Because PDCP expression is not altered by routine antiparkinsonian treatment, this measure of network activity may prove useful in clinical trials targeting the progression of non-motor manifestations of this disorder.

Indexed as

BrainCognitionCognition DisordersFemaleFluorodeoxyglucose F18HumansImage Processing, Computer-AssistedMaleMetabolic Networks and PathwaysMiddle AgedNerve NetNeuropsychological TestsParkinson DiseasePositron-Emission TomographyPrincipal Component AnalysisReproducibility of ResultsFluorodeoxyglucose F18

Identifiers

PMID17113310
PMCPMC4456012
OpenAlexW2091558603

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.