ArticleInternational journal for parasitology2007
Enzymes of type II fatty acid synthesis and apicoplast differentiation and division in Eimeria tenella.
Article in International journal for parasitology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 42 citations in OpenAlex.
- Modes and mechanisms for the inheritance of mitochondria and plastids in pathogenic protists.PLoS pathogens · 2025Review
- Global profiling of protein S-palmitoylation in the second-generation merozoites of Eimeria tenella.Parasitology research · 2024Article
- Eimeria proteins: order amidst disorder.Parasites & vectors · 2022Review
- TgAP2IX-5 is a key transcriptional regulator of the asexual cell cycle division in Toxoplasma gondii.Nature communications · 2021Article
- Life cycle stages, specific organelles and invasion mechanisms ofParasitology · 2020Review
- Selfish Mitonuclear Conflict.Current biology : CB · 2019Review
- Who Needs a Contractile Actomyosin Ring? The Plethora of Alternative Ways to Divide a Protozoan Parasite.Frontiers in cellular and infection microbiology · 2019Review
- Cryo-electron tomography reveals four-membrane architecture of the Plasmodium apicoplast.Malaria journal · 2013Article
- Article
- The apicomplexan Cryptosporidium parvum possesses a single mitochondrial-type ferredoxin and ferredoxin:NADP+ reductase system.Protein science : a publication of the Protein Society · 2010Article
- Identification and development of novel inhibitors of Toxoplasma gondii enoyl reductase.Journal of medicinal chemistry · 2010Article
- A Toxoplasma MORN1 null mutant undergoes repeated divisions but is defective in basal assembly, apicoplast division and cytokinesis.PloS one · 2010Article
- Proteomic comparison of four Eimeria tenella life-cycle stages: unsporulated oocyst, sporulated oocyst, sporozoite and second-generation merozoite.Proteomics · 2009Article
- Type II fatty acid synthesis is essential only for malaria parasite late liver stage development.Cellular microbiology · 2009Article
- Rab11A-controlled assembly of the inner membrane complex is required for completion of apicomplexan cytokinesis.PLoS pathogens · 2009Article
- Apicoplast and mitochondrion in gametocytogenesis of Plasmodium falciparum.Eukaryotic cell · 2009Article
- MORN1 has a conserved role in asexual and sexual development across the apicomplexa.Eukaryotic cell · 2008Article
- Type I and type II fatty acid biosynthesis in Eimeria tenella: enoyl reductase activity and structure.Parasitology · 2007Article
- Make it or take it: fatty acid metabolism of apicomplexan parasites.Eukaryotic cell · 2007Review
- Building the perfect parasite: cell division in apicomplexa.PLoS pathogens · 2007Review
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Authors and funding
15 authors at 6 institutions in 2 countries.
Funding
Abstract
Apicomplexan parasites, Eimeria tenella, Plasmodium spp. and Toxoplasma gondii, possess a homologous plastid-like organelle termed the apicoplast, derived from the endosymbiotic enslavement of a photosynthetic alga. However, currently no eimerian nuclear encoded apicoplast targeted proteins have been identified, unlike in Plasmodium spp. and T. gondii. In this study, we demonstrate that nuclear encoded enoyl reductase of E. tenella (EtENR) has a predicted N-terminal bipartite transit sequence, typical of apicoplast-targeted proteins. Using a combination of immunocytochemistry and EM we demonstrate that this fatty acid biosynthesis protein is located in the apicoplast of E. tenella. Using the EtENR as a tool to mark apicoplast development during the Eimeria lifecycle, we demonstrate that nuclear and apicoplast division appear to be independent events, both organelles dividing prior to daughter cell formation, with each daughter cell possessing one to four apicoplasts. We believe this is the first report of multiple apicoplasts present in the infectious stage of an apicomplexan parasite. Furthermore, the microgametes lacked an identifiable apicoplast consistent with maternal inheritance via the macrogamete. It was found that the size of the organelle and the abundance of EtENR varied with developmental stage of the E. tenella lifecycle. The high levels of EtENR protein observed during asexual development and macrogametogony is potentially associated with the increased synthesis of fatty acids required for the rapid formation of numerous merozoites and for the extracellular development and survival of the oocyst. Taken together the data demonstrate that the E. tenella apicoplast participates in type II fatty acid biosynthesis with increased expression of ENR during parasite growth. Apicoplast division results in the simultaneous formation of multiple fragments. The division mechanism is unknown, but is independent of nuclear division and occurs prior to daughter formation.
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