ArticleProceedings of the National Academy of Sciences of the United States of America1991
Developmental expression of the 25-kDa synaptosomal-associated protein (SNAP-25) in rat brain.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 117 citations in OpenAlex.
- Transcriptomic Analysis of CAD Cell Differentiation.microPublication biology · 2025Article
- Comparative analysis of potential broad-spectrum neuronal Cre drivers.Wellcome open research · 2022Article
- An innovative bioresorbable gelatin based 3D scaffold that maintains the stemness of adipose tissue derived stem cells and the plasticity of differentiated neurons.RSC advances · 2019Article
- SNARE complex in developmental psychiatry: neurotransmitter exocytosis and beyond.Journal of neural transmission (Vienna, Austria : 1996) · 2016Review
- Cytotoxicity of botulinum neurotoxins reveals a direct role of syntaxin 1 and SNAP-25 in neuron survival.Nature communications · 2013Article
- Neuronal death induced by nanomolar amyloid β is mediated by primary phagocytosis of neurons by microglia.The Journal of biological chemistry · 2011Article
- VAMP-2, SNAP-25A/B and syntaxin-1 in glutamatergic and GABAergic synapses of the rat cerebellar cortex.BMC neuroscience · 2011Article
- SNAP25 expression in mammalian retinal horizontal cells.The Journal of comparative neurology · 2011Article
- Activity-dependent regulation of MHC class I expression in the developing primary visual cortex of the common marmoset monkey.Behavioral and brain functions : BBF · 2011Article
- Article
- A neuronal role for SNAP-23 in postsynaptic glutamate receptor trafficking.Nature neuroscience · 2010Article
- Normal development of embryonic thalamocortical connectivity in the absence of evoked synaptic activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- SNAP-25a and -25b isoforms are both expressed in insulin-secreting cells and can function in insulin secretion.The Biochemical journal · 1999Article
- Characterization of a CNS cell line, CAD, in which morphological differentiation is initiated by serum deprivation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- Synaptic degeneration and remodelling after fast kindling of the olfactory bulb.Neurochemical research · 1996Article
- Cellubrevin and synaptobrevins: similar subcellular localization and biochemical properties in PC12 cells.The Journal of cell biology · 1995Article
- Differential expression of SNAP-25 protein isoforms during divergent vesicle fusion events of neural development.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Immediate upstream promoter regions required for neurospecific expression of SNAP-25.Journal of molecular neuroscience : MN · 1995Article
- Regulated vesicular fusion in neurons: snapping together the details.Proceedings of the National Academy of Sciences of the United States of America · 1994Review
- Novel inhibitory action of tunicamycin homologues suggests a role for dynamic protein fatty acylation in growth cone-mediated neurite extension.The Journal of cell biology · 1994Article
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4 authors at 1 institution in 1 country.
Funding
Abstract
The developmental expression and subcellular distribution of the neuron-specific 25-kDa synaptosomal protein (SNAP-25) were investigated by using Northern (RNA) blots, immunoblots, and immunocytochemistry. Both SNAP-25 protein and mRNA were present at low levels in embryonic day 15 rat brain, and levels of both increased during early postnatal maturation. Developmental immunoblots with antipeptide antisera demonstrated that a 25-kDa peptide was the major isoform in brain, and this form increased steadily from embryonic day 15 through adulthood. A second 27-kDa immunoreactive isoform was present in brain only during early development. Immunoblots of two-dimensional SDS/polyacrylamide gels revealed the presence of a predominant 25-kDa isoform of SNAP-25 in adult brain. Immunocytochemical studies indicated that as immunoreactivity for SNAP-25 increased during development, the cellular localization of SNAP-25 immunoreactivity concomitantly shifted from axons and cell bodies to presynaptic terminals. These data suggest that the SNAP-25 protein shifts in subcellular localization during development and may play a role in the establishment and stabilization of specific presynaptic terminals in brain.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.