ArticleProceedings of the National Academy of Sciences of the United States of America1991
Localized cytosolic domains of the erythropoietin receptor regulate growth signaling and down-modulate responsiveness to granulocyte-macrophage colony-stimulating factor.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 94 citations in OpenAlex.
- Erythropoietin receptor response circuits.Current opinion in hematology · 2010Review
- Dna damage-induced G(1) arrest in hematopoietic cells is overridden following phosphatidylinositol 3-kinase-dependent activation of cyclin-dependent kinase 2.Molecular and cellular biology · 2001Article
- GATA-1 dominantly activates a program of erythroid gene expression in factor-dependent myeloid FDCW2 cells.Molecular and cellular biology · 1998Article
- Mammalian granulocyte-macrophage colony-stimulating factor receptor expressed in primary avian hematopoietic progenitors: lineage-specific regulation of proliferation and differentiation.The Journal of cell biology · 1998Article
- Stoichiometric structure-function analysis of the prolactin receptor signaling domain by receptor chimeras.Molecular and cellular biology · 1998Article
- A proliferation switch for genetically modified cells.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Identification of tyrosine residues within the intracellular domain of the erythropoietin receptor crucial for STAT5 activation.The EMBO journal · 1996Article
- Tyrosine 343 in the erythropoietin receptor positively regulates erythropoietin-induced cell proliferation and Stat5 activation.The EMBO journal · 1995Article
- Activated Ki-Ras complements erythropoietin signaling in CTLL-2 cells, inducing tyrosine phosphorylation of a 160-kDa protein.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- High-efficiency identification of genes by functional analysis from a retroviral cDNA expression library.Journal of virology · 1994Article
- Murine pluripotent hematopoietic progenitors constitutively expressing a normal erythropoietin receptor proliferate in response to erythropoietin without preferential erythroid cell differentiation.Molecular and cellular biology · 1994Article
- A dominant negative erythropoietin (EPO) receptor inhibits EPO-dependent growth and blocks F-gp55-dependent transformation.Molecular and cellular biology · 1994Article
- Mutational analysis of a critical signaling domain of the human interleukin 4 receptor.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Multiple regions within the cytoplasmic domains of the leukemia inhibitory factor receptor and gp130 cooperate in signal transduction in hepatic and neuronal cells.Molecular and cellular biology · 1994Article
- Distinct cytoplasmic regions of the human granulocyte colony-stimulating factor receptor involved in induction of proliferation and maturation.Molecular and cellular biology · 1993Article
- Truncated erythropoietin receptor causes dominantly inherited benign human erythrocytosis.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- Isolation of interleukin 2-induced immediate-early genes.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- Distinct regions of the human granulocyte-colony-stimulating factor receptor cytoplasmic domain are required for proliferation and gene induction.Molecular and cellular biology · 1993Article
- Inactivation of erythropoietin receptor function by point mutations in a region having homology with other cytokine receptors.Molecular and cellular biology · 1993Article
- Distinct downstream signaling mechanism between erythropoietin receptor and interleukin-2 receptor.The EMBO journal · 1992Article
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2 authors at 1 institution in 1 country.
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Abstract
Erythrocyte development in mammals depends in part upon the interaction of the glycopeptide hormone erythropoietin (EPO) with cell surface receptors on committed erythroid progenitor cells. Both this factor and an EPO receptor polypeptide previously have been cloned, yet little is presently understood concerning molecular mechanisms of receptor activation and signal transduction. To identify cytosolic receptor domains necessary for signaling, we have compared the activities of a series of deletionally mutated EPO receptor constructs by their expression in interleukin 3-dependent, myeloid FDC-P1 cells. EPO-induced growth was transduced efficiently in these cells by the full-length receptor (507 amino acids), and no measurable loss in activity resulted from the deletion of up to 111 carboxyl-terminal residues. In contrast, the deletion of 44 additional residues led to a dramatic loss (86.3% +/- 7.8%; mean +/- SD) in the ability of this receptor to mediate EPO-induced growth, thus indicating that residues between Gly-352 and Met-396 constitute a functionally critical cytosolic subdomain. Interestingly, the expression of full-length EPO receptors in FDC-P1 cells also led to a selective inhibition of normal proliferative responsiveness to the alternative hematopoietic factor granulocyte-macrophage colony-stimulating factor. Moreover, this inhibition was progressively reversed in forms of the EPO receptor in which distal cytosolic residues were sequentially deleted. These results suggest that EPO receptors normally may trans-modulate components in the pathway of granulocyte-macrophage colony-stimulating factor-induced proliferation and that this down-modulation, as exerted by intact EPO receptors, may play a role in promoting erythroid commitment during myeloid blood cell development.
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