ArticleProceedings of the National Academy of Sciences of the United States of America1991
Retinoid-mediated transcriptional regulation of keratin genes in human epidermal and squamous cell carcinoma cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 101 citations in OpenAlex.
- Activated RARα counteracts the effects of TACC1v25 on the differentiation and invasion of head and neck squamous cell carcinoma.Translational cancer research · 2025Article
- Article
- Treatment of Recalcitrant Viral Warts with Combination Therapy of Systemic Acitretin and Diphenylcyclopropenone Immunotherapy.Annals of dermatology · 2020Article
- Serum lipids, retinoic acid and phenol red differentially regulate expression of keratins K1, K10 and K2 in cultured keratinocytes.Scientific reports · 2020Article
- A non-surgical approach for male germ cell mediated gene transmission through transgenesis.Scientific reports · 2013Article
- Regulation of keratin expression by retinoids.Dermato-endocrinology · 2011Article
- In vitro human keratinocyte migration rates are associated with SNPs in the KRT1 interval.PloS one · 2007Article
- Novel mechanism of steroid action in skin through glucocorticoid receptor monomers.Molecular and cellular biology · 2000Article
- Defining the regulatory factors required for epidermal gene expression.Molecular and cellular biology · 2000Article
- Transgenic studies with a keratin promoter-driven growth hormone transgene: prospects for gene therapy.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- The basal keratin network of stratified squamous epithelia: defining K15 function in the absence of K14.The Journal of cell biology · 1995Article
- A 5'-upstream region of a bovine keratin 6 gene confers tissue-specific expression and hyperproliferation-related induction in transgenic mice.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Transcriptional activation by Myc is under negative control by the transcription factor AP-2.The EMBO journal · 1995Article
- Oct-6: a regulator of keratinocyte gene expression in stratified squamous epithelia.Molecular and cellular biology · 1994Article
- An alternatively spliced mRNA from the AP-2 gene encodes a negative regulator of transcriptional activation by AP-2.Molecular and cellular biology · 1993Article
- Probing keratinocyte and differentiation specificity of the human K5 promoter in vitro and in transgenic mice.Molecular and cellular biology · 1993Article
- Terminal differentiation in keratinocytes involves positive as well as negative regulation by retinoic acid receptors and retinoid X receptors at retinoid response elements.Molecular and cellular biology · 1992Article
- Close linkage of retinoic acid receptor genes with homeobox- and keratin-encoding genes on paralogous segments of mouse chromosomes 11 and 15.Mammalian genome : official journal of the International Mammalian Genome Society · 1992Article
- Transcription factor AP2 and its role in epidermal-specific gene expression.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Vitamin A and other retinoids profoundly inhibit morphological and biochemical features of epidermal differentiation in vivo and in vitro. To elucidate the molecular mechanisms underlying the differential expression of epidermal keratins and their regulation by retinoids, we examined retinoid-mediated changes in total protein expression, protein synthesis, mRNA expression, and transcription in cultured human keratinocytes and in squamous cell carcinoma (SCC-13) cells of epidermal origin. Our studies revealed that the epidermal keratins, K5, K6, K14, and K16, their mRNAs, and their transcripts were diminished relative to actin as a consequence of retinoic acid (RA) treatment. The effects were most pronounced in SCC-13 and were detected as early as 6 hr post-RA treatment, with enhancement over an additional 24-48 hr. Repression was also observed when 5' upstream sequences of K14 or K5 genes were used to drive expression of a chloramphenicol acetyltransferase reporter gene in SCC-13 keratinocytes. Both cell types were found to express mRNAs for the RA receptors alpha and gamma, which may be involved in the RA-mediated transcriptional changes in these cells. The rapid transcriptional changes in epidermal keratin genes were in striking contrast to the previously reported slow transcriptional changes in simple epithelial keratin genes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.