ArticleJournal of Zhejiang University. Science. B2006
Imbalanced free radicals and antioxidant defense systems in schizophrenia: a comparative study.
Article in Journal of Zhejiang University. Science. B, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 62 citations in OpenAlex.
- The Pathobiological Underpinnings of Psychosis: From the Stress-Related Hypothesis to a Multisystemic Approach.NeuroSci · 2025Review
- Intranasal delivery of blackberry-loaded Chitosan nanoparticles for antipsychotic potential in Ketamine-induced schizophrenia in rats.Scientific reports · 2025Article
- Positive Effects of Uric Acid on White Matter Microstructures and Treatment Response in Patients With Schizophrenia.Schizophrenia bulletin · 2024Article
- Oxidative Stress and Emergence of Psychosis.Antioxidants (Basel, Switzerland) · 2022Review
- High Throughput Identification of the Potential Antioxidant Peptides inMolecules (Basel, Switzerland) · 2022Article
- Role of Oxidative Stress and the Identification of Biomarkers Associated With Thyroid Dysfunction in Schizophrenics.Frontiers in pharmacology · 2021Article
- Regulation of Reactive Oxygen Species-Mediated Damage in the Pathogenesis of Schizophrenia.Brain sciences · 2020Review
- Plasma total antioxidant status and cognitive impairments in first-episode drug-naïve patients with schizophrenia.Cognitive neurodynamics · 2019Article
- Galantamine-Memantine Combination as an Antioxidant Treatment for Schizophrenia.Current behavioral neuroscience reports · 2019Article
- Pretreatment With Risperidone Ameliorates Systemic LPS-Induced Oxidative Stress in the Cortex and Hippocampus.Frontiers in neuroscience · 2018Article
- Mitochondrial Dysfunction in Schizophrenia: Determination of Mitochondrial Respiratory Activity in a Two-Hit Mouse Model.Journal of molecular neuroscience : MN · 2016Article
- Oxidative stress and level of antioxidant enzymes in drug-naive schizophrenics.Indian journal of psychiatry · 2014Article
- Polyphenols from Berries of Aronia melanocarpa Reduce the Plasma Lipid Peroxidation Induced by Ziprasidone.Schizophrenia research and treatment · 2014Article
- Generation of superoxide anion radicals and platelet glutathione peroxidase activity in patients with schizophrenia.Neuropsychiatric disease and treatment · 2014Article
- Antioxidants as potential therapeutics for neuropsychiatric disorders.Progress in neuro-psychopharmacology & biological psychiatry · 2013Review
- The oxidative stress may be induced by the elevated homocysteine in schizophrenic patients.Neurochemical research · 2012Article
- Epicatechin inhibits human plasma lipid peroxidation caused by haloperidol in vitro.Neurochemical research · 2012Article
- Different effects of L-arginine on morphine tolerance in sham and ovariectomized female mice.Journal of Zhejiang University. Science. B · 2011Article
- Oxidative stress in schizophrenia.Current neuropharmacology · 2011Article
- Oxidative stress in schizophrenia: an integrated approach.Neuroscience and biobehavioral reviews · 2011Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo examine changes of blood oxidative-antiovidative level in schizophrenic patients and its relationship with clinical symptoms.
methodsForty-six Chinese patients met DSM-IV (Diagnostic and Statistical Manual of Mental Disorders-IV) criteria for schizophrenia and fifty age- and sex-matched healthy controls were enrolled in the present study. Baseline psychiatric symptom severity was assessed with brief psychiatric rating scale, positive and negative syndrome scale on the blood draw day. Fresh blood samples were collected to measure levels of nitric oxide and lipid peroxide in plasma as well as activities of superoxide dismutase, catalase and glutathione peroxidase in red blood cells by spectrophotometric assays simultaneously.
resultsComparison of the biochemical parameters indicated that the level of nitric oxide and lipid peroxide increased in patient group, which represented a positive correlation with positive scale scores; while the activities of three critical enzymes decreased and showed a negative linear correlation.
conclusionThis study showed that there are dysregulation of free radical metabolism and poor activities of the antioxidant defense systems in schizophrenic patients. Excess free radicals formation may play a critical role in the etiology of schizophrenia. Using antioxidants might be an effective therapeutic approach to partially alleviate or prevent the symptoms of schizophrenia.
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