ArticleClinical oral investigations2007
High-molecular tenascin-C as an indicator of atypical cells in oral brush biopsies.
Article in Clinical oral investigations, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Diagnostic tests for oral cancer and potentially malignant disorders in patients presenting with clinically evident lesions.The Cochrane database of systematic reviews · 2021Pooled it
- Diagnostic tests for oral cancer and potentially malignant disorders in patients presenting with clinically evident lesions.The Cochrane database of systematic reviews · 2015Pooled it
- Evaluation of the Ki-67 and MCM3 Expression in Cytologic Smear of Oral Squamous Cell Carcinoma.Journal of dentistry (Shiraz, Iran) · 2017Article
- Tenascin-C and fibronectin expression divide early stage tongue cancer into low- and high-risk groups.British journal of cancer · 2017Article
- Clinical and cytological study of the oral mucosa of smoking and non-smoking qat chewers in Yemen.Clinical oral investigations · 2016Article
- Efficacy of Oral Brush Biopsy without Computer-Assisted Analysis in Oral Premalignant and Malignant Lesions: A Study.Journal of international oral health : JIOH · 2015Article
- Tenascin-C: Form versus function.Cell adhesion & migration · 2015Review
- Tenascin-C and carcinoma cell invasion in oral and urinary bladder cancer.Cell adhesion & migration · 2015Review
- Use of endoscopy with narrow-band imaging system in detecting squamous cell carcinoma in oral chronic non-healing ulcers.Clinical oral investigations · 2014Article
- Diagnostic efficiency of differentiating small cancerous and precancerous lesions using mucosal brush smears of the oral cavity--a prospective and blinded study.Clinical oral investigations · 2011Article
- MAGE-A antigens in lesions of the oral mucosa.Clinical oral investigations · 2011Article
- Oral squamous cell cancer: early detection and the role of alcohol and smoking.Head & neck oncology · 2011Review
- Techniques for precancerous lesion diagnosis.Journal of oncology · 2011Article
- Immunohistochemical expression of basement membrane proteins of verrucous carcinoma of the oral mucosa.Clinical oral investigations · 2010Article
- Molecular mechanisms of head and neck cancer.Expert review of anticancer therapy · 2008Review
- [Oral cytology: historical development, current status, and perspectives].Mund-, Kiefer- und Gesichtschirurgie : MKG · 2007Review
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tumour-invasion like wound healing is characterised by the formation of an extracellular matrix with a high tenascin-C content. The tenascin-C molecule undergoes alternative splicing. Analysis using antibody BC2 indicates that especially the high-molecular tenascin-C (hm tn-C) variants are typically tumour-associated, while distribution in normal tissue is restrictive. This study investigated whether hm tn-C is a suitable indicator of atypical cells with invasive potential in oral brush biopsies. One hundred fifty nine consecutive oral brush biopsies with histopathological diagnoses were analysed for the identification of atypical cells. A standardised haematoxylin and eosin staining plus standardised immunocytochemistry using the monoclonal anti-hm tn-C antibody was performed. The bound hm tn-C antibodies were detected with the streptavidine/alkaline phosphatase technique in the autostainer. Conventional cytology produced four false-positives when identifying atypical cells in brush biopsies of inflammatory/benign hyperproliferative mucosa (specificity 96%), while 10 in 52 carcinomas and three of eight recurrences were not identified (sensitivity 78%). Ten of these 13 non-identified tumours could be marked when adding the hm tn-C assay (increasing specificity to 99%). Combining the two assays also reduced the false-positive outcomes from four to one (increasing sensitivity to 95%). The positive and negative predictive values were 92 and 88% for conventional cytology vs 98 and 97% for the dual assay. (1) A 95%-sensitivity proves hm tn-C assisted conventional cytology to be a suitable means of identifying atypical cells in oral brush biopsies. (2) The positive (98%) and negative (97%) predictive values obtained approximate hm tn-C assisted conventional cytology to laminin-5 (100/97%).
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