Evidence map›Paper›PMID 17110955›Full record

ReviewNature reviews. Immunology2006

Protozoan encounters with Toll-like receptor signalling pathways: implications for host parasitism.

Ricardo T Gazzinelli, Eric Y Denkers

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Immunology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 148 papers.

0numbers the graph read from it
0cells of the map it votes in
148citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

148 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
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  13. Lipid and fatty acid metabolism in trypanosomatids.Microbial cell (Graz, Austria) · 2021
    Review
  14. Article
  15. Article
  16. Article
  17. Frontiers in cell and developmental biology · 2021
    Article
  18. Biological and Molecular Effects ofFrontiers in cellular and infection microbiology · 2021
    Article
  19. Review
  20. Virulence ofFrontiers in cellular and infection microbiology · 2021
    Article

88 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ricardo T GazzinelliDepartment of Biochemistry and Immunology, Federal University of Minas Gerais, 31270-901 Belo Horizonte, Brazil. ricardo.gazzinelli@umassmed.edu
Eric Y Denkers

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Toll-like receptors (TLRs) have emerged as a major receptor family involved in non-self recognition. They have a vital role in triggering innate immunity and orchestrate the acquired immune response during bacterial and viral infection. However, the role of TLRs during infection with protozoan pathogens is less clear. Nevertheless, our understanding of how these parasitic microorganisms engage the host TLR signalling system has now entered a phase of rapid expansion. This Review describes recent insights into how parasitic protozoans are sensed by TLR molecules, and how the TLR system itself can be targeted by these microbial pathogens for their own survival.

Indexed as

AnimalsEukaryotaHost-Parasite InteractionsMiceProtozoan InfectionsSignal TransductionToll-Like ReceptorsToll-Like Receptors

Identifiers

PMID17110955

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.