ArticleThe EMBO journal2006
Increased frequency of homologous recombination and T-DNA integration in Arabidopsis CAF-1 mutants.
Article in The EMBO journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.
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Who cites it
84 citing papers in PubMed, 165 citations in OpenAlex.
- The genomic landscape of recombination in rice revealed by a large nested association mapping population.The New phytologist · 2026Article
- TONSOKU prevents the formation of large tandem duplications and restrains ATR-WEE1 checkpoint activation.Nature communications · 2026Article
- Chromatin remodeling by HIRA and FAS2 restricts geminivirus pathogenesis in plants.Virology journal · 2026Article
- Defective transfer of parental histone decreases frequency of homologous recombination by increasing free histone pools in budding yeast.Nucleic acids research · 2024Article
- A review of the potential involvement of small RNAs in transgenerational abiotic stress memory in plants.Functional & integrative genomics · 2024Review
- Genomic consequences associated with Agrobacterium-mediated transformation of plants.The Plant journal : for cell and molecular biology · 2024Review
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- Enhancing HR Frequency for Precise Genome Editing in Plants.Frontiers in plant science · 2022Article
- G2/M-checkpoint activation in fasciata1 rescues an aberrant S-phase checkpoint but causes genome instability.Plant physiology · 2021Article
- Targeted DNA insertion in plants.Proceedings of the National Academy of Sciences of the United States of America · 2021Review
- Alterations in hormonal signals spatially coordinate distinct responses to DNA double-strand breaks inScience advances · 2021Article
- Precision genome editing in plants: state-of-the-art in CRISPR/Cas9-based genome engineering.BMC plant biology · 2020Review
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- Activities of Chromatin Remodeling Factors and Histone Chaperones and Their Effects in Root Apical Meristem Development.International journal of molecular sciences · 2020Review
- Precise gene replacement in plants through CRISPR/Cas genome editing technology: current status and future perspectives.aBIOTECH · 2020Review
- Review
- Article
- Challenges and Perspectives in Homology-Directed Gene Targeting in Monocot Plants.Rice (New York, N.Y.) · 2019Review
- Plant condensin II is required for the correct spatial relationship between centromeres and rDNA arrays.Nucleus (Austin, Tex.) · 2019Article
24 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chromatin assembly factor 1 (CAF-1) is involved in nucleo some assembly following DNA replication and nucleotide excision repair. In Arabidopsis thaliana, the three CAF-1 subunits are encoded by FAS1, FAS2 and, most likely, MSI1, respectively. In this study, we asked whether genomic stability is altered in fas1 and fas2 mutants that are lacking CAF-1 activity. Depletion of either subunit increased the frequency of somatic homologous recombination (HR) in planta approximately 40-fold. The frequency of transferred DNA (T-DNA) integration was also elevated. A delay in loading histones onto newly replicated or repaired DNA might make these DNA stretches more accessible, both to repair enzymes and to foreign DNA. Furthermore, fas mutants exhibited increased levels of DNA double-strand breaks, a G2-phase retardation that accelerates endoreduplication, and elevated levels of mRNAs coding for proteins involved in HR-all factors that could also contribute to upregulation of HR frequency in fas mutants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.