ArticleGenetics2007
Fine mapping reveals sex bias in quantitative trait loci affecting growth, skeletal size and obesity-related traits on mouse chromosomes 2 and 11.
Article in Genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 40 citations in OpenAlex.
- Harnessing natural variation to identify cis regulators of sex-biased gene expression in a multi-strain mouse liver model.PLoS genetics · 2021Article
- Mapping novel genetic loci associated with female liver weight variations using Collaborative Cross mice.Animal models and experimental medicine · 2018Article
- Burly1 is a mouse QTL for lean body mass that maps to a 0.8-Mb region of chromosome 2.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Article
- Adiposity QTL Adip20 decomposes into at least four loci when dissected using congenic strains.PloS one · 2017Article
- Overlapping mouse subcongenic strains successfully separate two linked body fat QTL on distal MMU 2.BMC genomics · 2015Article
- Article
- Leptin receptor interacts with rat chromosome 1 to regulate renal disease traits.Physiological genomics · 2012Article
- Quantitative trait locus mapping of genes that control body length and plasma insulin-like growth factor 1 level in mice.BMC research notes · 2012Article
- Understanding the sexome: measuring and reporting sex differences in gene systems.Endocrinology · 2012Review
- Article
- Architecture of energy balance traits in emerging lines of the Collaborative Cross.American journal of physiology. Endocrinology and metabolism · 2011Article
- Intersubspecific subcongenic mouse strain analysis reveals closely linked QTLs with opposite effects on body weight.Mammalian genome : official journal of the International Mammalian Genome Society · 2011Article
- Cognitive effects of genetic variation in monoamine neurotransmitter systems: a population-based study of COMT, MAOA, and 5HTTLPR.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2011Article
- A new mapping method for quantitative trait loci of silkworm.BMC genetics · 2011Article
- Article
- Fine-mapping of obesity-related quantitative trait loci in an F9/10 advanced intercross line.Obesity (Silver Spring, Md.) · 2010Article
- Congenic and bioinformatics analyses resolved a major-effect Fob3b QTL on mouse Chr 15 into two closely linked loci.Mammalian genome : official journal of the International Mammalian Genome Society · 2010Article
- Increased physical activity cosegregates with higher intake of carbohydrate and total calories in a subcongenic mouse strain.Mammalian genome : official journal of the International Mammalian Genome Society · 2010Article
- Sex differences in phenotypic plasticity affect variation in sexual size dimorphism in insects: from physiology to evolution.Annual review of entomology · 2010Review
- The genetics of quantitative traits: challenges and prospects.Nature reviews. Genetics · 2009Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Previous speed congenic analysis has suggested that the expression of growth and obesity quantitative trait loci (QTL) on distal mouse chromosomes (MMU) 2 and 11, segregating between the CAST/EiJ (CAST) and C57BL/6J-hg/hg (HG) strains, is dependent on sex. To confirm, fine map, and further evaluate QTL x sex interactions, we constructed congenic by recipient F2 crosses for the HG.CAST-(D2Mit329-D2Mit457)N(6) (HG2D) and HG.CAST-(D11Mit260-D11Mit255)N(6) (HG11) congenic strains. Over 700 F2 mice were densely genotyped and phenotyped for a panel of 40 body and organ weight, skeletal length, and obesity-related traits at 9 weeks of age. Linkage analysis revealed 20 QTL affecting a representative subset of phenotypes in HG2DF2 and HG11F2 mice. The effect of sex was quantified by comparing two linear models: the first model included sex as an additive covariate and the second incorporated sex as an additive and an interactive covariate. Of the 20 QTL, 8 were sex biased, sex specific, or sex antagonistic. Most traits were regulated by single QTL; however, two closely linked loci were identified for five traits in HG2DF2 mice. Additionally, the confidence intervals for most QTL were significantly reduced relative to the original mapping results, setting the stage for quantitative trait gene (QTG) discovery. These results highlight the importance of assessing the contribution of sex in complex trait analyses.
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Registered trials
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