ArticleGenetics2007
Accumulation of deleterious mutations in small abiotic populations of RNA.
Article in Genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Ribozyme Mutagenic Evolution: Mechanisms of Survival.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2021Article
- Limits of neutral drift: lessons from the in vitro evolution of two ribozymes.Journal of molecular evolution · 2014Article
- Low selection pressure aids the evolution of cooperative ribozyme mutations in cells.The Journal of biological chemistry · 2013Article
- Intra-tumor heterogeneity: lessons from microbial evolution and clinical implications.Genome medicine · 2013Review
- Article
- Sex, mutations and marketing. How the Cambrian explosion set the stage for runaway consumerism.EMBO reports · 2012Article
- Quasispecies-like behavior observed in catalytic RNA populations evolving in a test tube.BMC evolutionary biology · 2010Article
- Niche partitioning in the coevolution of 2 distinct RNA enzymes.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Muller's Ratchet and compensatory mutation in Caenorhabditis briggsae mitochondrial genome evolution.BMC evolutionary biology · 2008Article
- Collective properties of evolving molecular quasispecies.BMC evolutionary biology · 2007Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The accumulation of slightly deleterious mutations in populations leads to the buildup of a genetic load and can cause the extinction of populations of small size. Mutation-accumulation experiments have been used to study this process in a wide variety of organisms, yet the exact mutational underpinnings of genetic loads and their fitness consequences remain poorly characterized. Here, we use an abiotic system of RNA populations evolving continuously in vitro to examine the molecular events that can instigate a genetic load. By tracking the fitness decline of ligase ribozyme populations with bottleneck sizes between 100 and 3000 molecules, we detected the appearance and subsequent fixation of both slightly deleterious mutations and advantageous mutations. Smaller populations went extinct in significantly fewer generations than did larger ones, supporting the notion of a mutational meltdown. These data suggest that mutation accumulation was an important evolutionary force in the prebiotic RNA world and that mechanisms such as recombination to ameliorate genetic loads may have been in place early in the history of life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.