ArticleBlood2007
Expression of a non-DNA-binding isoform of Helios induces T-cell lymphoma in mice.
Article in Blood, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Identification of germline monoallelic mutations in IKZF2 in patients with immune dysregulation.Blood advances · 2022Article
- Three-dimensional chromatin landscapes in T cell acute lymphoblastic leukemia.Nature genetics · 2020Article
- Helios: still behind the clouds.Immunology · 2019Review
- IKZF2 Drives Leukemia Stem Cell Self-Renewal and Inhibits Myeloid Differentiation.Cell stem cell · 2019Article
- Role of a non-canonical splice variant of theOncology letters · 2018Article
- Genetic alterations in adult T-cell leukemia/lymphoma.Cancer science · 2017Review
- Helios expression coordinates the development of a subset of striatopallidal medium spiny neurons.Development (Cambridge, England) · 2017Article
- Expression patterns of Ikaros family members during positive selection and lineage commitment of human thymocytes.Immunology · 2016Article
- Variations in mRNA and protein levels of Ikaros family members in pediatric T cell acute lymphoblastic leukemia.Annals of translational medicine · 2016Article
- Helios-controller of Treg stability and function.Translational cancer research · 2016Article
- Integrated molecular analysis of adult T cell leukemia/lymphoma.Nature genetics · 2015Article
- Phenotype and regulation of immunosuppressive Vδ2-expressing γδ T cells.Cellular and molecular life sciences : CMLS · 2014Article
- Article
- Adult T-cell leukemia cells are characterized by abnormalities of Helios expression that promote T cell growth.Cancer science · 2013Article
- Helios marks strongly autoreactive CD4+ T cells in two major waves of thymic deletion distinguished by induction of PD-1 or NF-κB.The Journal of experimental medicine · 2013Article
- Article
- Helios transcription factor expression depends on Gsx2 and Dlx1&2 function in developing striatal matrix neurons.Stem cells and development · 2012Article
- Article
- A role for the transcription factor Helios in human CD4(+)CD25(+) regulatory T cells.Molecular immunology · 2010Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Helios is a zinc-finger protein belonging to the Ikaros family of transcriptional regulators. It is expressed, along with Ikaros, throughout early stages of thymocyte development where it quantitatively associates with Ikaros through C-terminal zinc-finger domains that mediate heterodimerization between Ikaros family members. To understand the role of Helios in T-cell development, we used a retroviral vector to express full-length Helios or a Helios isoform that lacked the N-terminal DNA-binding domain in hematopoietic progenitor cells of reconstituted mice. Constitutive expression of full-length Helios resulted in an inhibition of T-cell development at the double-negative stage within the thymus. Although expression of the DNA-binding mutant of Helios did not contribute to developmental abnormalities at early times after transplantation, 60% of animals that expressed the Helios DNA-binding mutant developed an aggressive and transplantable T-cell lymphoma 4 to 10 months after transplantation. These results demonstrate a vital function for Helios in maintaining normal homeostasis of developing T cells and formally show that non-DNA-binding isoforms of Helios are lymphomagenic if aberrantly expressed within the T-cell lineage.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.